. "Cholesterol je esenci\u00E1ln\u00ED a v\u00FDznamn\u00FD nutrient u kriticky nemocn\u00FDch."@cs . . . "Poruchy synt\u00E9zy cholesterolu a jeho deplece - klinick\u00E9 d\u016Fsledky a mo\u017Enosti jeho l\u00E9\u010Debn\u00E9ho ovlivn\u011Bn\u00ED v intenzivn\u00ED p\u00E9\u010Di" . " cholesterol synthesis" . . . "2011-04-27+02:00"^^ . "2006-01-01+01:00"^^ . . "1"^^ . . "1"^^ . . . "hypocholesterolaemia" . "4"^^ . . . "The proposed project is a local, monocentric, prospective clinical study. Probands are the patients after cardiac and abdominal surgery, traumatized patients and critical ill in the intensive care units. The aim of the project is to find dependency of serious hypocholesterolaemias on the source of cholesterol, impact on adrenal function and to outline possible early diagnosis and supplementation strategy. The following laboratory tests will be performed - determination of sterols, insulin, interleukin Il-6, stimulation ACTH test as a test of adrenal functional capacity and functional capacity of granulocytes will be determined using oxidative burst test.. Due to high requirements on cholesterol supply in critical disease, a human organism can be deprived of cholesterol. It is aggravated by its consumption for steroid synthesis. Moreower, most critical patients are on cholesterol - deficient nutrition."@en . "4"^^ . "Disturbances of synthesis of cholesterol and its depletion - clinical consequences and opportunities of terapeutical influence in intensive care"@en . "0"^^ . "2008-03-05+01:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=NR8921"^^ . . . "hypocholesterolaemia; cholesterol synthesis; critical care"@en . . "Cholesterol is an imported and esential nutrient in critical ill patients."@en . "Jedn\u00E1 se o lok\u00E1ln\u00ED, monocentrickou, prospektivn\u00ED klinickou studii. Do studie budou za\u0159azeni nemocn\u00ED po kardiochirurgick\u00FDch v\u00FDkonech, traumatizovan\u00ED nemocn\u00ED, nemocn\u00ED po operac\u00EDch na GIT a kriticky nemocn\u00ED na jednotce intern\u00ED intenzivn\u00ED p\u00E9\u010De. C\u00EDlem studie bude sledovat frekvenci z\u00E1va\u017En\u00FDch hypocholesterolemi\u00ED v z\u00E1vislosti na charakteru metabolismu cholesterolu pacienta, jejich vliv na funkci nadledvin a nast\u00EDnit mo\u017Enosti v\u010Dasn\u00E9 diagnostiky a p\u0159\u00EDpadn\u00E9 suplementace. Metodami, vyu\u017E\u00EDvan\u00FDmi ve studii bude stanoven\u00ED hladiny sterol\u016F, inzulinu, interleukinu IL-6, stimula\u010Dn\u00ED ACTH test jako test funk\u010Dn\u00ED zdatnosti nadledvin a sledov\u00E1n\u00ED funk\u010Dn\u00ED zdatnosti granulocyt\u016F pomoc\u00ED testu ingesce mikrob\u016F a %22oxidative burst%22 testu. Cholesterol je velmi pravd\u011Bpodobn\u011B podm\u00EDn\u011Bn\u011B esenci\u00E1ln\u00EDm nutrientem a nelze tedy vylou\u010Dit stav deprivace p\u0159i zv\u00FD\u0161en\u00FDch n\u00E1roc\u00EDch na dod\u00E1vku reparuj\u00EDc\u00EDm se tk\u00E1n\u00EDm, co\u017E vy\u017Eaduje podrobn\u00E9 zkoum\u00E1n\u00ED vzhledem k sv\u00FDm velmi pravd\u011Bpodobn\u00FDm n\u00E1sledk\u016Fm." . . . "2008-12-31+01:00"^^ . "NR8921" . .