. . . "0"^^ . "The project has accomplished all objectives laid out. Results enable to identify clinical factors in DCIS connected with invasion, recurrence and metastatic spread into axillary lymphonodes."@en . "2011-04-27+02:00"^^ . "0"^^ . " invasion" . "DCIS; sentinel node; invasion; prognostic factors"@en . "1"^^ . "NR8807" . . "2006-01-01+01:00"^^ . "Prediktivn\u00ED a prognostick\u00E9 faktory u DCIS." . . "DCIS" . "Na z\u00E1klad\u011B klinicko-patologick\u00FDch a molekul\u00E1rn\u011B-biochemick\u00FDch vlastnost\u00ED DCIS je mo\u017En\u00E9 identifikovat pacientky se zv\u00FD\u0161en\u00FDm rizikem recidivy, invaze a vzniku metast\u00E1z. Takto selektovan\u00FDm pacientk\u00E1m s vysok\u00FDm rizikem recidivy a generalizace onemocn\u011Bn\u00ED m\u016F\u017Eeme nab\u00EDdnout agresivn\u011Bj\u0161\u00ED l\u00E9\u010Dbu s c\u00EDlem dos\u00E1hnout vy\u0161\u0161\u00ED kuratibility a t\u00EDm zv\u00FD\u0161it po\u010Det vyl\u00E9\u010Den\u00FDch pacientek. Exprese gen\u016F, jejich\u017E produkty se pod\u00EDlej\u00ED na mechanismech kl\u00ED\u010Dov\u00FDch pro n\u00E1dorovou invazi - angiogenezi (VEGF), adhezi (FAK) a regulaci bun\u011B\u010Dn\u00E9ho cyklu (p63) v DCIS je v p\u0159\u00EDm\u00E9 souvislosti s biologick\u00FDm chov\u00E1n\u00EDm n\u00E1doru. Proveden\u00ED biopsie SN v lok\u00E1ln\u00ED anestezii zkr\u00E1t\u00ED a zjednodu\u0161\u00ED opera\u010Dn\u00ED v\u00FDkon a t\u00EDm sn\u00ED\u017E\u00ED po\u010Det poopera\u010Dn\u00EDch komplikac\u00ED a celkovou z\u00E1t\u011B\u017E pacientky." . " sentinel node" . "The factors in DCIS(grading, typing, necroses, hormonal receptors, Her-2, topography of microcalcifications and molecular biologic characteristics) could predict invasion, recurrence or metastasis to axillary lymph nodes. On the basis of clinical-pathologic and molecular biologic characteristics of DCIS (especially its high-risk forms) it is possible to identify patients with an increased risk of disease progression to the generalized stage. This will enable us to offer these patients a more radical and more effective type of treatment with a curative aim. Performing SN biopsy under local anesthesia will shorten and simplify the surgical procedure and thus will also decrease the number of postoperative complications and overall stress on the patient."@en . "\u0158e\u0161en\u00ED projektu splnilo formou z\u00E1v\u011Bre\u010Dn\u00E9 zpr\u00E1vy v\u0161echny anotovan\u00E9 c\u00EDle. Umo\u017Enilo identifikovat klinick\u00E9 faktory u DCIS, kter\u00E9 mohou predikovat invazivitu, rekurenci a metastatick\u00E9 posti\u017Een\u00ED axil\u00E1rn\u00EDch uzlin."@cs . "http://www.isvav.cz/projectDetail.do?rowId=NR8807"^^ . "5"^^ . "5"^^ . . . . . . . . "Predictive and prognostic factors in DCIS."@en . . . . "2008-12-31+01:00"^^ . . . . . "2008-03-05+01:00"^^ .