"2008-03-05+01:00"^^ . " depression" . "2011-04-27+02:00"^^ . . "1"^^ . "1"^^ . "2006-01-01+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NR8806"^^ . "0"^^ . . "VYBRAN\u00C9 NUTRI\u010CN\u00CD A GENETICK\u00C9 FAKTORY V PATOGENEZE METABOLICK\u00C9HO SYNDROMU A DEPRESIVN\u00CDCH PORUCH" . " homocysteine" . . . . . "C\u00EDle tohoto projektu spln\u011Bny v term\u00EDnu, ale s omezen\u00FDm po\u010Dtem pacient\u016F s depresivn\u00ED poruchou (n=41), co\u017E omezuje validitu genetick\u00FDch vy\u0161et\u0159en\u00ED.Na z\u00E1klad\u011B 4 publikac\u00ED v \u010Dasopisech s IF se v\u0161ak p\u0159ikl\u00E1n\u00EDm ke kategorii A"@cs . . " genetic polymorphisms" . . " oxidative stres" . "The project\u00B4s targets were fulfilled in time but with limited number of depresive subjects (n=41). This could lead to falsely positive results of genetic analysis.Nevertheless, on the basis of 4 publications in journals with IF I suggest evaluation A."@en . . " PUFA n-3" . . "The interactions between components of metabolic syndrome and depression, dietary pattern, profiles of PUFA in plasma lipids, homocysteine, parameters of oxidative stress as well as inflammation, selected cytokines and BDNF in serum will be analysed. The hypothesis about the causal relation between the deficiency of PUFA n-3, high homocysteine, oxidative stress in development of metabolic syndrome and depression and effect of selected genetic polymorphisms on these relations will be tested."@en . . "metabolic syndrome" . "Budou analyzov\u00E1ny vztahy mezi komponentami metabolick\u00E9ho syndromu a depres\u00ED, slo\u017Een\u00EDm diety, koncentracemi PUFA v lipidech plazmy, homocysteinu, ukazateli oxida\u010Dn\u00EDho stresu a z\u00E1n\u011Btu, vybran\u00FDmi cytokiny a mozkov\u00FDm neurotrofick\u00FDm faktorem v s\u00E9ru Bude testov\u00E1na hypot\u00E9za o kauz\u00E1ln\u00EDm vztahu mezi deficienc\u00ED PUFA n-3, zv\u00FD\u0161enou koncentrac\u00ED homocysteinu, oxida\u010Dn\u00EDm stresem p\u0159i rozvoji metabolick\u00E9ho syndromu a deprese a vlivu vybran\u00FDch genetick\u00FDch polymorfizm\u016F na tyto vztahy." . . . "NR8806" . "24"^^ . " BDNF" . . "24"^^ . "SELECTED NUTRITIONAL AND GENETIC FACTORS IN THE PATHOGENESIS OF METABOLIC SYNDROME AND DEPRESSIVE DISORDERS"@en . . . "metabolic syndrome; depression; PUFA n-3; homocysteine; oxidative stres; BDNF; genetic polymorphisms; inflammation"@en . . . "2008-12-31+01:00"^^ .