"NR8758" . . "0"^^ . "1"^^ . . . . "The main objective of this project is the early identification of patients with chronic myeloid leukemia at high risk of resistance to imatinib (Glivec, STI571). We are going to introduce the method of ASO PCR with sensitivity 0,01% in order to early detect mutations associated with poor prognosis. Further early markers of the resistance will be tested by molecular and cytogenetic techniques"@en . . "CML; imatinib; resistance; early markers; mutations; ASO PCR"@en . " mutations" . "Identification of time point for valid mutation analysis with predictive significance for resistency/relaps of CML"@en . "0"^^ . "Early markers of resistance to imatinib in chronic myeloid leukemia treatment"@en . . . "2008-12-31+01:00"^^ . . . "\u010Casn\u00E9 markery rezistence k imatinibu p\u0159i l\u00E9\u010Db\u011B chronick\u00E9 myeloidn\u00ED leukemie" . . . " early markers" . . "2006-01-01+01:00"^^ . " resistance" . . . . "CML" . "2008-03-05+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NR8758"^^ . . "2011-04-27+02:00"^^ . " imatinib" . . . "N\u00E1lez \u010Dasov\u00E9ho \u00FAseku pro zah\u00E1jen\u00ED prov\u00E1d\u011Bn\u00ED muta\u010Dn\u00EDch analyz s predik\u010Dn\u00EDm v\u00FDznamem pro detekci rezistence/relapsu CML."@cs . "C\u00EDlem pr\u00E1ce je nal\u00E9zt mo\u017Enosti \u010Dasn\u00E9 identifikaci pacient\u016F s vysok\u00FDm rizikem vzniku rezistence na imatinib (Glivec, STI571). Bude zavedena metoda ASO PCR s citlivost\u00ED 0,01% k detekci mutac\u00ED v kin\u00E1zov\u00E9 dom\u00E9n\u011B BCR-ABL. Pomoc\u00ED cytogenetick\u00FDch a molekul\u00E1rn\u011B genetick\u00FDch metod budou hled\u00E1ny dal\u0161\u00ED \u010Dasn\u00E9 markery rezistence." . "7"^^ . "7"^^ .