. "Combination of molecularly biological structural and enzymological methods characterized the origin of HIV resistance of HIV against inhibitors of proteases. New compounds /metallacarborans/ inhiting mutant proteases"@en . "HIV; protease; sequencing; inhibitor; resistance; mutation; therapy; AIDS"@en . . . . "The project involves analysis of resistance development in HIV-positive patients treated by protease inhibitors in the CR, design of novel, non-infectious phenotypic resistance assays and design of novel inhibitors, active against resistant forms of HIV."@en . . . " inhibitor" . "NR8571" . "2007-03-02+01:00"^^ . "2007-12-31+01:00"^^ . " sequencing" . "2008-09-16+02:00"^^ . . " resistance" . "2005-01-01+01:00"^^ . " therapy" . "Projekt navrhuje sledov\u00E1n\u00ED vzniku resistence u HIV-positivn\u00EDch pacient\u016F v \u010CR, v\u00FDvoj nov\u00FDch, jednoduch\u00FDch neinfek\u010Dn\u00EDch metod testov\u00E1n\u00ED resistence a n\u00E1vrh nov\u00FDch strukturn\u00EDch typ\u016F inhibitor\u016F, aktivn\u00EDch v\u016F\u010Di resistentn\u00EDm form\u00E1m HIV." . . "1"^^ . "1"^^ . . . . . "Molecular characterisation of resistant mutants of viral protease from HIV-positive patients developed under the selection pressure of protease inhibitors: design of novel inhibitors and diagnostics for individualised molecular medicine"@en . . "0"^^ . . . " mutation" . "HIV" . . "http://www.isvav.cz/projectDetail.do?rowId=NR8571"^^ . . "6"^^ . "Molekul\u00E1rn\u00ED charakterisace resistentn\u00EDch forem virov\u00E9 proteasy z HIV-positivn\u00EDch pacient\u016F vznikl\u00FDch pod selek\u010Dn\u00EDm tlakem inhibitor\u016F proteasy: n\u00E1vrh nov\u00FDch inhibitor\u016F a diagnostick\u00FDch postup\u016F pro individualisovanou molekul\u00E1rn\u00ED medic\u00EDnu" . "6"^^ . . . " protease" . . "Kombinac\u00ED molekul\u00E1rn\u011B biologick\u00FDch, struktur\u00E1ln\u00EDch a enzymologick\u00FDch metod byl charakterizov\u00E1n vznik rezistence HIV v\u016F\u010Di inhibitor\u016Fm prote\u00E1z. Navr\u017Eeny nov\u00E9 slou\u010Deniny /metallakarborany/ inhibuj\u00EDc\u00ED mutantn\u00ED prote\u00E1zy."@cs .