" metabolizing enzymes genes" . "carcinogenesis; genetic polymorphismus; metabolizing enzymes genes; repair DNA enzymes genes; oncological diseases; gene expression; gen repair and functional test"@en . "1"^^ . "3"^^ . "Hodnocen\u00ED polymorfism\u016F a jejich vz\u00E1jemn\u00FDch vztah\u016F u gen\u016F DNA reparace a u gen\u016F \u00FA\u010Dastn\u00EDc\u00EDch se biotransformace u pacient\u016F s n\u00E1dorov\u00FDm onemocn\u011Bn\u00EDm a u zdrav\u00FDch kontrol v \u010Desk\u00E9 populaci. Porovn\u00E1n\u00ED profil\u016F expres\u00ED XME a DNA repara\u010Dn\u00EDch gen\u016F s genetick\u00FDmi profily a konfrontace s v\u00FDsledky funk\u010Dn\u00EDch test\u016F. Zaveden\u00ED metod pro stanoven\u00ED jednonukleotidov\u00E9ho polymorfismu (SNP) v r\u016Fzn\u00FDch DNA repara\u010Dn\u00EDch genech (XPA, hOGG1, APE1 a NBS1). DNA bude izolov\u00E1na z leukocyt\u016F a XME i DNA repara\u010Dn\u00ED genetick\u00E9 polymorfismy budou stanovov\u00E1ny metodou PCR-RFLP." . " oncological diseases" . . . "0"^^ . "2005-01-01+01:00"^^ . . . . . . "Rozs\u00E1hl\u00FD projekt hodnot\u00EDc\u00ED polymorfismy gen\u016F jako prediktivn\u00EDch faktor\u016F u onkologick\u00FDch pacient\u016F v porovn\u00E1n\u00ED se zdrav\u00FDmi kontrolami.V\u00FDsledky byly bohat\u011B publikov\u00E1ny."@cs . . "A vast project assessing polymorphisms in genes as predicative factors by oncology patients in comparison to healthy controls. Results have been often published."@en . . "2011-04-27+02:00"^^ . "Genetick\u00FD profil gen\u016F metabolismu xenobiotik a DNA reparace u pacient\u016F s novotvary a u kontroln\u00EDch osob v \u010Cesk\u00E9 republice." . "2009-12-31+01:00"^^ . . "Evaluation of links between individual genetic background - evaluation of polymorphisms in both DNA repair and XME genes and expression levels in lymphocytes in cancer patients and healthy controls in Czech Republic. Determination of expression profiles of DNA repair and XME genes in comparison with genetic profiles and outcomes from the functional tests. A study on genotype-phenotype relations with special regard to prognosis and therapy outcome."@en . . . . " repair DNA enzymes genes" . . . "24"^^ . . "24"^^ . "carcinogenesis" . . . " gene expression" . . "NR8563" . " genetic polymorphismus" . "http://www.isvav.cz/projectDetail.do?rowId=NR8563"^^ . "2009-12-18+01:00"^^ . . "Genetic profile of biotransformation and DNA repair genes in cancer patients from the Czech Republic."@en .