. "Rheologic, functional, and structural aspects of atherogenesis: the impact of extracorporeal hemorheotherapy on microcirculation"@en . "NR8505" . . . . "2005-01-01+01:00"^^ . . . "P\u0159edm\u011Btem v\u00FDzkumu je l\u00E9\u010Debn\u00E9 ovlivn\u011Bn\u00ED rheologick\u00FDch pom\u011Br\u016F v mikrocirkulaci metodou extrakorpor\u00E1ln\u00ED hemorheoterapie u c\u00E9vn\u00EDch komplikac\u00ED akcelerovan\u00E9 atherosklerosy p\u0159i hyperlipoprotenemi\u00EDch. K tomu byla zavedena l\u00E9\u010Dba kask\u00E1dovou filtrac\u00ED. Metodika: Filtry zachyt\u00ED lipoproteiny, ale i fibrinogen, alfa2-makroglobulin, n\u011Bkter\u00E9 imunoglobuliny, zejm\u00E9na IgM. Jde o prospektivn\u00ED studii k ov\u011B\u0159en\u00ED v\u00FDznamu v\u00FD\u0161e uveden\u00FDch parametr\u016F a l\u00E9\u010Deb.v\u00FDsledk\u016F procedur u c\u00E9vn\u00EDch komplikac\u00ED atherosklerosy. Krom\u011B b\u011B\u017En\u00FDch zaji\u0161\u0165ovac\u00EDch vy\u0161et\u0159en\u00ED bude sledov\u00E1no: spektrum lipoprotein\u016F, adhezn\u00EDch molekul (S-, P-selektinu, MCP-1 a endotelinu), parametry trombocyt\u016F, rheologick\u00E1 vy\u0161et\u0159en\u00ED (viskosita, deformabilita erytrocyt\u016F, fibrinogen, alfa2makroglobulin). \u0158e\u0161en\u00ED p\u0159isp\u011Bje k zdokonalen\u00ED l\u00E9\u010Dby t\u011B\u017Ek\u00FDch poruch u nemocn\u00FDch a bude mo\u017En\u00E1 \u00FAsp\u011B\u0161n\u00E1 a bezpe\u010Dn\u00E1 l\u00E9\u010Dba i v n\u011Bkter\u00FDch indikac\u00EDch, kde dosud standardn\u00ED terapie selh\u00E1vala. P\u0159edpokl\u00E1daj\u00ED se technick\u00E1 zjednodu\u0161en\u00ED l\u00E9\u010Dby a \u00FAspory." . "2007-12-31+01:00"^^ . "Rheologick\u00E9, funk\u010Dn\u00ED a struktur\u00E1ln\u00ED aspekty aterogeneze: ovlivn\u011Bn\u00ED mikrocirkulace metodou extrakorpor\u00E1ln\u00ED hemorheoterapie" . . . "2007-03-01+01:00"^^ . . " Rheopheresis" . . "0"^^ . "Blood-vessel complications at the less usual diagnosis \u2013 sudden loss of hearing and disorders of microcirculation in s\u00EDtnice in patients with atherosclerosis and pharmacologically influenced hypercholesterolemia"@en . "1"^^ . . . . . "0"^^ . " LDL-apheresis" . . "Projekt se zab\u00EDval metodou, kter\u00E1 m\u016F\u017Ee b\u00FDt pou\u017Eita k zlep\u0161en\u00ED c\u00E9vn\u00EDch komplikac\u00ED i u m\u00E9n\u011B obvykl\u00FDch diagn\u00F3z-n\u00E1hl\u00E1 ztr\u00E1ta sluchu a poruchy mikrocirkulace v s\u00EDtnici u nemocn\u00FDch s ateroskler\u00F3zou a farmakologicky h\u016F\u0159e ovlivnitelnou hypercholesterolemi\u00ED."@cs . . "The research objective is therapeutic affection of rheologic conditions in microcirculation with extracorporeal hemorheotherapy in vascular complications of accelerated atherosclerosis in hyperlipoproteinemias.Cascade filtration was introduced. Methods: Filters catch lipoproteins, but also fibrinogen, alfa2-macroglobulin,certain immunoglobulins,especially IgM. It is a prospective study for verification of the importance of above mentioned parameters and therapeutic results of procedures. Follow-up of parameters not included in routine safe guarding examinations: lipoprotein spectrum, adhesive molecules (S-, P-selectin, MCP-1 and endothelin), thrombocyte parameters, rheologic examinations (viscosity,erythrocyte deformability, fibrinogen). The resolution will contribute to the improvement of therapy in severe disorders of the patients, and successful and safe therapy will be possible in those infications where standard therapy failed."@en . "2008-09-16+02:00"^^ . . " Immunoapheresis" . "15"^^ . "atherosclerosis; Immunoapheresis; LDL-apheresis; Rheopheresis; cascade filtration"@en . . "15"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=NR8505"^^ . "atherosclerosis" .