" ELISA" . . . . " cognitive impairment" . . " cerebrospinal fluid" . . "C\u00EDlem projektu je ur\u010Den\u00ED vztahu mezi formou ALS (bulb\u00E1rn\u00ED,\u010Di kon\u010Detinovou), kognitivn\u00ED alterac\u00ED a markery neurodegenerace. Princip spo\u010D\u00EDv\u00E1 v komplexn\u00EDm vy\u0161et\u0159en\u00ED pacient\u016F (neuropsychologick\u00E9 testy, anal\u00FDza likvoru, MRI volumometrie a SPECT) v dob\u011B stanoven\u00ED diagnozy a zopakov\u00E1n\u00ED s \u010Dasov\u00FDm odstupem. Neuropatologick\u00E9 vy\u0161et\u0159en\u00ED mozkov\u00E9 tk\u00E1n\u011B zhodnot\u00ED typ a stupe\u0148 posti\u017Een\u00ED CNS Ke stanoven\u00ED protil\u00E1tek proti neurofilament\u016Fm v likvoru bude vyvinuta vlastn\u00ED ELISA metodika Z\u00EDskan\u00E9 v\u00FDsledky p\u0159isp\u011Bj\u00ED k lep\u0161\u00EDmu pochopen\u00ED patofyziologie ALS i k up\u0159esn\u011Bn\u00ED progn\u00F3zy onemocn\u011Bn\u00ED v okam\u017Eiku stanoven\u00ED diagn\u00F3zy." . "The research project has brought new data which allow new insight into the pathophysiology of cognitive disorder accompanying amyotrophic lateral sclerosis."@en . "2005-01-01+01:00"^^ . . "The aim of the study is to establish correlations between the the form of ALS (bulbar or limb onset), cognitive impairment and markers of neurodegeneration. The study is based on a complex initial evaluation of ALS patients (neuropsychological tests, cerebrospinal fluid analysis, MRI volumometry and SPECT), repeated after a constant delay. A proper ELISA method for the detection of CSF anti-neurofilament antibodies will be developed. The obtained results will contribute to become a better insight into the pathophysiology of the disease as well as to identify more accurate prognostic factors."@en . "2011-04-27+02:00"^^ . . . . . " neurofilaments" . "http://www.isvav.cz/projectDetail.do?rowId=NR8491"^^ . " tau protein" . . . . "1"^^ . . "1"^^ . " neuropsychology" . "The relationship between amyotrophic lateral sclerosis and the degree of cognitive impairment, markers of neurodegeneration and brain atrophy. A prospective study."@en . "ALS" . "Byly z\u00EDsk\u00E1ny nov\u00E9 poznatky, t\u00FDkaj\u00EDc\u00ED se patofyziologie kognitivn\u00EDho deficitu doprov\u00E1zej\u00EDc\u00EDho onemocn\u011Bn\u00ED amyotrofickou later\u00E1ln\u00ED skler\u00F3zou."@cs . "2008-12-31+01:00"^^ . "0"^^ . "ALS; neuropsychology; cognitive impairment; cerebrospinal fluid; tau protein; neurofilaments; ELISA; MRI volumometry"@en . "Ur\u010Den\u00ED vztahu mezi formou amyotrofick\u00E9 later\u00E1ln\u00ED skler\u00F3zy a stupn\u011Bm kognitivn\u00ED alterace, markery neurodegenerace a mozkov\u00E9 atrofie - prospektivn\u00ED studie" . . . "11"^^ . . "NR8491" . "11"^^ . "2008-03-05+01:00"^^ . .