. . . "2005-01-01+01:00"^^ . . "V\u00FDsledek \u0159e\u0161en\u00ED spo\u010D\u00EDv\u00E1 p\u0159edev\u0161\u00EDm v prohlouben\u00ED znalost\u00ED o imunologii nosn\u00ED sliznice, o os\u00EDdlen\u00ED nosn\u00ED sliznice S. aureus a v prohlouben\u00ED znalost\u00ED o defensinech."@cs . "The result of the solution lies in deepening the knowledge on immunology of nose mucosa, colonization of nose mucosa with S. Aureus and deepening the knowledge about defensives"@en . . . "The relation between the occurence of the bacteria Staphylococcus aureus on the mucosa of the nose and paranasal sinusis and mucosal antimicrobial activity expressed by the presence of defensins"@en . "2007-03-01+01:00"^^ . "Staphylococcus aureus is often found as part of the normal microflora of the upper respiratory tract especially the vestibulum na\u0161\u00ED.Pathogenicity of S.aureus is closely corellated with production of toxins with superantigenic properties. The pathogenicity of S.aureus is closely correlated with the production of a variety of toxins with superantigenic properties which can influence the activity of both immunomodulatory and pro inflammatory effector cells. The pathogenicity of S.aureus is closely correlated with the production of a variety of toxins with superantigenic properties which can influence the activity of both immunomodulatory and pro inflammatory effector cells. Beta defensin 1 may play a constitutive role in nasal defense, whereas beta defensin 2 may be inducted in response to local infection or inflammation.Beta defensin 3 has significant bactericidal activity against Gram positive S."@en . . "defensins beta; Staphylococcus aureus; nasal mucosis; rhinosinusitis; nasal polyposis"@en . . . "2007-12-31+01:00"^^ . " rhinosinusitis" . " nasal mucosis" . . "defensins beta" . "http://www.isvav.cz/projectDetail.do?rowId=NR8440"^^ . . . . "0"^^ . "0"^^ . "2"^^ . "2"^^ . "1"^^ . . "NR8440" . . . "2008-09-16+02:00"^^ . . . "Sledov\u00E1n\u00ED vztahu mezi bakteri\u00E1ln\u00EDm os\u00EDdlen\u00EDm sliznice nosn\u00ED a vedlej\u0161\u00EDch dutin nosn\u00EDch patogenem Staphylococcus aureus a jej\u00ED antimikrobi\u00E1ln\u00ED aktivitou, vyj\u00E1d\u0159enou p\u0159\u00EDtomnost\u00ED defensin\u016F" . " Staphylococcus aureus" . "Staphylococcus aureus tvo\u0159\u00ED \u010Dasto sou\u010D\u00E1st norm\u00E1ln\u00ED mikroflory sliznice horn\u00EDch cest d\u00FDchac\u00EDch a p\u0159edev\u0161\u00EDm sliznice nosn\u00EDho vestibula.Patogenita S.aureus \u00FAzce souvis\u00ED s produkc\u00ED r\u016Fzn\u00FDch toxin\u016F, kter\u00E9 vykazuj\u00ED superantigenn\u00ED vlastnosti. Patogenita S.aureus \u00FAzce souvis\u00ED s produkc\u00ED r\u016Fzn\u00FDch toxin\u016F, kter\u00E9 vykazuj\u00ED superantigenn\u00ED vlastnosti. Tyto superantigeny maj\u00ED vliv na aktivitu imunomodula\u010Dn\u00EDch a proz\u00E1n\u011Btliv\u00FDch bun\u011Bk a hraj\u00ED tak roli v patogenezi chronick\u00FDch z\u00E1n\u011Btliv\u00FDch nemoc\u00ED. Byly pops\u00E1ny t\u0159i skupiny beta defensin\u016F 1-3, HBD 1-3. U v\u0161ech byla prok\u00E1z\u00E1na antimikrobi\u00E1ln\u00ED aktivita. HBD 1 hraje roli v p\u0159irozen\u00E9 obran\u011B nosn\u00ED sliznice,HBD 2 je indukov\u00E1n lok\u00E1ln\u00ED infekc\u00ED nebo z\u00E1n\u011Btem. HBD 3 m\u00E1 baktericidn\u00ED aktivitu proti S.aureus." .