"Anal\u00FDza klinick\u00E9ho stavu a imunitn\u00EDch funkc\u00ED u HIV+ jedinc\u016F bez dlouhodob\u00E9 progrese a u pacient\u016F nereaguj\u00EDc\u00EDch odpov\u00EDdaj\u00EDc\u00EDm zp\u016Fsobem na st\u00E1vaj\u00EDc\u00ED l\u00E9\u010Dbu, se snahou o stanoven\u00ED korel\u00E1tu imunity v evoluci HIV infekce" . "HIV infection; cytokine; ELISPOT; MHC tetramers; T lymfocytes????; HAART; LTNPs; IMMUNITY?"@en . "1"^^ . . . "0"^^ . "1"^^ . "1"^^ . " LTNPs" . . . "NR8305" . . "0"^^ . . " cytokine" . . "Institution responsible for the project did not fullfil anotated aims."@en . . . . . . . "http://www.isvav.cz/projectDetail.do?rowId=NR8305"^^ . . . "Poskytovatel opakovan\u011B neshledal re\u00E1lnost dosa\u017Een\u00ED v\u00FDsledk\u016F dle schv\u00E1len\u00E9 anotace projektu z d\u016Fvodu nedodr\u017Een\u00ED harmonogramu \u010Dinnost\u00ED v\u010D. \u010Dast\u00FDch person\u00E1ln\u00EDch zm\u011Bn \u010Dlen\u016F z\u00E1kladn\u00EDho \u0159e\u0161itelsk\u00E9ho t\u00FDmu."@cs . "MHC tetramers were used to determine the frequence of HIV-specific CD8 T cells in 63 HIV-positive patients. It was shown that 48% of naive and 34% of HAART - treated patients have detectable levels of Gag-specific CD8 T cells in peripheral blood."@en . " MHC tetramers" . "Analyzing clinical status and immune functions of HIV+ individuals without long-term progression (LTNPs) and patients not responding satisfactory to therapy with monitoring the numbers and function of HIV-specific T lymphocytes. Introducing new methods for evaluation of number and function of specific T lymphocytes - MHC tetramers and ELISPOTs. Analyzing results of new and standard immunological tests of individuals without long-term progression (LTNPs) and of patients not responding to therapy. Determination of applicable immunological new markers improve the prediction of the evolution of HIV infection and optimize the indication of the start (or interruption) of antiretroviral treatment or iniciate other possibilities - e.g. immunotherapy."@en . "Pro ur\u010Den\u00ED frekvence HIV-specifick\u00FDch CD8 T bun\u011Bk byla u 63 HIV-pozitivn\u00EDch pacient\u016F pou\u017Eita metoda MHC tetrametr\u016F. Uk\u00E1zalo se, \u017Ee detekovateln\u00E9 hladiny Gag-specifick\u00FDch CD8 T lymfocyt\u016F v perifern\u00ED krvi m\u00E1 48% nel\u00E9\u010Den\u00FDch a 34% u pacient\u016F l\u00E9\u010Den\u00FDch HAART."@cs . "2007-08-08+02:00"^^ . . " ELISPOT" . " HAART" . . "Anal\u00FDza klinick\u00E9ho stavu a imunitn\u00EDch funkc\u00ED u HIV+ jedinc\u016F bez dlouhodob\u00E9 progrese(LTNPs) a u nereaguj\u00EDc\u00EDch odpov\u00EDdaj\u00EDc\u00EDm zp\u016Fsobem na sou\u010Dasnou l\u00E9\u010Dbu v podm\u00EDnk\u00E1ch \u010CR s pomoc\u00ED stanoven\u00ED HIV specifick\u00FDch T lymfocyt\u016F - jejich po\u010Dtu a funkce. Zaveden\u00ED nov\u00FDch metod umo\u017Enuj\u00EDch studium po\u010Dtu a funkce specifick\u00FDch T lymfocyt\u016F - MHC tetram\u00E9ry a ELISPOTy. Anal\u00FDza nov\u011B zaveden\u00FDch a standardn\u00EDch vy\u0161et\u0159en\u00ED imunitn\u00EDho syst\u00E9mu u jedinc\u016F bez dlouhodob\u00E9 progrese (LTNPs) a u pacient\u016F nereaguj\u00EDch na terapii. Stanoven\u00ED vhodn\u00FDch imunologick\u00FDch korel\u00E1t\u016F, nov\u00FDch marker\u016F progrese HIV infekce zp\u0159esn\u00ED predikci klinick\u00E9ho v\u00FDvoje, optimalizuje \u010Dasov\u00FD moment pro nasazen\u00ED pop\u0159. p\u0159eru\u0161en\u00ED antiretrovirov\u00E9 terapie nebo vy\u00FAst\u00ED do dal\u0161\u00EDch l\u00E9\u010Debn\u00FDch postup\u016F-nap\u0159.imunoterapie" . "Analysis of clinical status and immune functions of HIV positive individuals without progression of the disease and patients not responding to antiretroviral treatment; the determination of immune protection correlates in evolution of HIV infection."@en . . "HIV infection" . " T lymfocytes????" . .