" cancer" . . "2008-09-16+02:00"^^ . . . . "HNPCC; Colorectal; cancer; MLH1; MSH2; MSH6; MYH"@en . "Study of genetic predispositions to colorectal cancer"@en . . "2007-03-02+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NR8294"^^ . " MLH1" . . " Colorectal" . . . . "New knowledge about etiopathogenesis of colorectal tumors in CZ. Contribution for the area of genetic advisory and testing on risky patients in CZ \u2013 possibility of efficient testing of genetic predispositions to colorectal tumors"@en . "HNPCC" . . . . "We will study germline mutations in the MLH1, MSH2, MSH6, and MYH genes as a possible molecular cause of the disease in patients with colorectal cancer (CRC) and positive family history of CRC by using methods of molecular genetics. Results of the project will add to the understanding of molecular basis of colorectal carcinogenesis and to identification of novel genetically determined risk factors of the colorectal cancer development."@en . " MSH2" . "Nov\u00E9 poznatky o etiopatogenezi n\u00E1dor\u016F kolorekta v \u010CR. P\u0159\u00EDnos pro oblast genetick\u00E9ho poradenstv\u00ED a testov\u00E1n\u00ED u rizikov\u00FDch pacient\u016F v \u010CR - mo\u017Enost efektivn\u00EDho testov\u00E1n\u00ED gentet.predispozice k n\u00E1dor\u016Fm kolorekta."@cs . . "Studium genetick\u00FDch predispozic k zhoubn\u00FDm n\u00E1dor\u016Fm tlust\u00E9ho st\u0159eva" . . " MSH6" . "0"^^ . . "2005-01-01+01:00"^^ . "1"^^ . . "Metodami molekul\u00E1rn\u00ED genetiky budou zkoum\u00E1ny z\u00E1rode\u010Dn\u00E9 mutace gen\u016F MLH1, MSH2, MSH6 a MYH jako mo\u017En\u00E1 molekul\u00E1rn\u00ED p\u0159\u00ED\u010Dina onemocn\u011Bn\u00ED u nemocn\u00FDch s karcinomem tlust\u00E9ho st\u0159eva (CRC) a v\u00FDskytem CRC v rodin\u011B. \u0158e\u0161en\u00ED projektu p\u0159isp\u011Bje k dal\u0161\u00EDmu pozn\u00E1n\u00ED molekul\u00E1rn\u00ED podstaty kolorekt\u00E1ln\u00ED kancerogeneze a k identifikaci nov\u00FDch geneticky podm\u00EDn\u011Bn\u00FDch rizikov\u00FDch faktor\u016F pro vznik CRC." . . "2"^^ . . "0"^^ . "2007-12-31+01:00"^^ . . "2"^^ . "NR8294" .