. . " silica" . " asbestos" . " leukotriene B4" . . "2007-08-08+02:00"^^ . . . "oxidant stress; asbestos; silica; isoprostane; leukotriene B4; ANCA; laboratory; diagnostics"@en . "oxidant stress" . "1"^^ . " ANCA" . . "1"^^ . . "NR8107" . . " isoprostane" . "method for simultaneous evaluation of 8-isoprostane and leukotrien B4 based on immunoaffinity separation and LC/NS in a condensate of expired breath air was developed. Increased level of 8-isoprost. as surrogate marker of oxidative stress in pneumoconias"@en . . "Paraleln\u00ED stanoven\u00ED 8-izoprostanu a leukotrienu B4v kondenz\u00E1tu vydechovan\u00E9ho vzduchu metodou imunoafinitn\u00ED separace a LC/NS. Zv\u00FD\u0161en\u00E1 hladina 8-izoprostanu z\u00E1visl\u00E1 na d\u00E1vce fibrogenn\u00EDho prachu je pova\u017Eov\u00E1na za marker oxidativn\u00EDho stresu u pneumokoni\u00F3z."@cs . "0"^^ . . . . "Nalezen\u00ED optim\u00E1ln\u00ED metody pro anal\u00FDzu 8-izoprostanu a leukotrienu B4 v kondenz\u00E1tu vydechovan\u00E9ho vzduchu pomoc\u00ED kombinace vysoce citliv\u00FDch metod -kapalinov\u00E9 chromatografie, ionizace elektrosprejem a tandemov\u00E9 hmotnostn\u00ED spektrometrie (LC-ESI-MS-MS). Stanovov\u00E1n\u00ED 8-izoprostanu jako markeru oxidativn\u00EDho stresu v kondenz\u00E1tu vydechovan\u00E9ho vzduchu u pacient\u016F se silik\u00F3zou, azbest\u00F3zou a zdrav\u00FDch dobrovoln\u00EDk\u016F. Stanovov\u00E1n\u00ED leukotrienu B4 jako markeru z\u00E1n\u011Btu v kondenz\u00E1tu vydechovan\u00E9ho vzduchu u pacient\u016F se silik\u00F3zou, azbest\u00F3zou a zdrav\u00FDch dobrovoln\u00EDk\u016F. Zhodnocen\u00ED mo\u017Enosti vyu\u017Eit\u00ED marker\u016F v diferenci\u00E1ln\u00ED diagnostice plicn\u00EDch onemocn\u011Bn\u00ED a k \u010Dasn\u00E9 diagnostice oxidativn\u00EDho stresu a z\u00E1n\u011Btu v oblasti respira\u010Dn\u00EDho syst\u00E9mu." . . . . "Ascertainment of oxidant stress in persons exposed to fibrogenic dusts"@en . "http://www.isvav.cz/projectDetail.do?rowId=NR8107"^^ . " laboratory" . . . "Zji\u0161\u0165ov\u00E1n\u00ED oxidativn\u00EDho stresu u osob s expozic\u00ED fibrogenn\u00EDm prach\u016Fm." . "Finding optimal method for the analysis of 8-isoprostane and leukotriene B4 in exhaled breath condensate using combination of highly sensitive methods - liquid chromatography, ionisation electrospraying and tandem mass spectrometry (LC-ESI-MS-MS). Determination of 8-isoprostane as a marker of oxidant stress in exhaled breath condensate in patients with silicosis, diseases due to asbestos and healthy volunteers. Determination of leukotriene B4 as a marker of inflammation in exhaled breath condensate in patients with silicosis, diseases due to asbestos and healthy volunteers. Evaluation of the use of the markers in the differential diagnostics of lung diseases and in the early diagnostics of oxidant stress and inflammation in the respiratory system."@en . . . "28"^^ . "28"^^ .