. . " ion channel" . . . "Syndrom dlouh\u00E9ho QT intervalu je geneticky podm\u00EDn\u011Bn\u00E9 onemocn\u011Bn\u00ED spojen\u00E9 s vysok\u00FDm v\u00FDskytem malign\u00EDch komorov\u00FDch arytmi\u00ED a n\u00E1hl\u00E9 smrti. V polovin\u011B p\u0159\u00EDpad\u016F je p\u0159\u00ED\u010Dinou mutace gen\u016F pro podjednotky 3 iontov\u00FDch kan\u00E1l\u016F myokardu. Podkladem tohoto onomocn\u011Bn\u00ED o dal\u0161\u00EDch pacient\u016F mohou b\u00FDt po\u0161kozen\u00ED dal\u0161\u00EDch iontov\u00FDch kan\u00E1l\u016F, kter\u00E9 hraj\u00ED v\u00FDznamnou roli v ak\u010Dn\u00EDm potenci\u00E1lu kadiomyocyt\u016F. Syndrom dlouh\u00E9ho QT intervalu vytv\u00E1\u0159\u00ED model arytmogeneze na molekul\u00E1rn\u00ED \u00FArovni." . . . . " sudden death" . "arrhytmias" . "NR8063" . . . . . " mutation" . . . "http://www.isvav.cz/projectDetail.do?rowId=NR8063"^^ . "The Long QT syndrome is a genetically determined disease associated with high risk of malignant ventricular arrhytmias and sudden death. Half of the cases is caused by mutation of genes for 3 myocardial ion channels. Alteration of other ion channel, which play important role in action potential of cardiomyocytes, could form the disease background in the other patients. The long QT syndrome forms a molecular level of arrhytmogenesis."@en . "arrhytmias; gene; ion channel; mutation; sudden death; long QT syndrome; QT interval"@en . "5"^^ . "5"^^ . . "2007-08-08+02:00"^^ . "1"^^ . . " gene" . . "1"^^ . . "New test of detection of gene mutations or polymorphisms in LQTS were introduced. This offers new dimension in both diagnostic and therapeutic methods in patients with abnormal cardiac repolarization."@en . "Auto\u0159i zavedli dal\u0161\u00ED labor.testy pro muta\u010Dn\u00ED anal\u00FDzu kandid\u00E1tn\u00EDch gen\u016F u syndromu dlouh\u00E9ho QT.To umo\u017E\u0148uje p\u0159esn\u011Bj\u0161\u00ED genetickou diagnostiku vrozen\u00FDch i z\u00EDskan\u00FDch arytmick\u00FDch syndrom\u016F a perspektivn\u011B t\u00E9\u017E posouzen\u00ED progn\u00F3zy pacienta a v\u00FDb\u011Br \u00FA\u010Dinn\u011Bj\u0161\u00ED l\u00E9\u010Dby."@cs . . . "Mutation analysis of candidate genes of long QT syndrome"@en . . " long QT syndrome" . "0"^^ . "Muta\u010Dn\u00ED anal\u00FDza kandid\u00E1tn\u00EDch gen\u016F syndromu dlouh\u00E9ho QT intervalu." .