. . "1"^^ . . " hyperlipidemia" . "0"^^ . " alpha-tocopherol" . " LDL-apheresis" . . . " fatty acids" . . . . "http://www.isvav.cz/projectDetail.do?rowId=NR8062"^^ . . "23"^^ . . "Nestabiln\u00ED ateromov\u00FD pl\u00E1t: mo\u017Enosti ovlivn\u011Bn\u00ED prognosy klinicky z\u00E1va\u017En\u00E9 org\u00E1nov\u00E9 aterosklerosy" . . . "23"^^ . . . " cholesterol" . . "In addition to LDL-cholesterol redution, LDL-aphaeresis significantly improves the developmnet of atherosclerosis, which is associated with other lipid-related including endothelial dysfunction and chronic inflammation."@en . "Prospective clinical study of the mutual interactions and particular role of fundamental lipid related atherogenic mechanisms in patients with severe hypercholesterolemia treated by low density lipoprotein apheresis. Project will investigate changes and correlation of the i) cholesterol biosynthetic pathway and its intermediary products, metabolism and absorption, ii) plasma and cell membrane unsaturated and saturated fatty acids. Futher examination will focus on iii) lipoperoxidation processes and antioxidant consumption. The results might improve our knowledge and thus treatment of atherosclerosis, which is the leading cause of morbidity and mortality in Czech Republic."@en . "2007-08-08+02:00"^^ . . "Unstable ateromatous plaque: the possibilities to influence the prognosis of clinically important organ atherosclerosis"@en . . "Pozitivn\u00ED vliv l\u00E9\u010Dby LDL afer\u00E9zou na proces aterogeneze nespo\u010D\u00EDv\u00E1 pouze v mechanick\u00E9m odstran\u011Bn\u00ED LDL-cholesterolu, ale jsou tak\u00E9 ovlivn\u011Bny dal\u0161\u00ED lipidov\u00E9 parametry aterogeneze v\u010D. dysfunkce endotelu a chronick\u00E9ho z\u00E1n\u011Btu."@cs . "Prospektivn\u00ED klinick\u00E1 studie vz\u00E1jemn\u00E9 interakce a \u00FAlohy nejd\u016Fle\u017Eit\u011Bj\u0161\u00EDch lipidov\u00FDch aterogenn\u00EDch mechanism\u016F u pacient\u016F se z\u00E1va\u017Enou hypercholesterol\u00E9mi\u00ED, l\u00E9\u010Den\u00FDch LDL (low density lipoprotein) afer\u00E9zou. Projekt, kter\u00FD navazuje na p\u0159edchoz\u00ED v\u00FDsledky \u0159e\u0161itelsk\u00E9ho t\u00FDmu, bude zkoumat zm\u011Bny a korelace n\u00E1sleduj\u00EDc\u00EDch parametr\u016F: i) biosynt\u00E9za cholesterolu a jeho intermedi\u00E1rn\u00EDch produkt\u016F. Dal\u0161\u00ED anal\u00FDza bude hodnotit ii) nenasycen\u00E9 a nasycen\u00E9 mastn\u00E9 kyseliny v plasm\u011B a bun\u011B\u010Dn\u00E9 membr\u00E1n\u011B, iii) pr\u016Fb\u011Bh lipoperoxidace a konsumpce antioxidant\u016F. Z\u00EDskan\u00E9 poznatky mohou p\u0159isp\u011Bt k objasn\u011Bn\u00ED a t\u00EDm i k l\u00E9\u010Db\u011B procesu ateroskler\u00F3zy, kter\u00E1 je nej\u010Dast\u011Bj\u0161\u00ED p\u0159\u00ED\u010Dinou morbidity a mortality v \u010Cesk\u00E9 republice." . . "atherosclerosis; hyperlipidemia; cholesterol; alpha-tocopherol; LDL-apheresis; fatty acids; lipoperoxidation"@en . "atherosclerosis" . "NR8062" . . . "0"^^ .