"2007-08-08+02:00"^^ . " cellular therapy" . "peripheral artery disease; vasculogenesis; cellular therapy; endothelial precursors; bone marrow blood; mobilisation; statins; G-CSF"@en . . . " endothelial precursors" . . "\u00DA\u010Dinnost autologn\u00ED transpl.d\u0159e\u0148 bun.intraart.cestou a srovn\u00E1n\u00ED s efektem inf.aplik.prostanoid\u016F jako mobilizace endot.prekurzor\u016F. Pr\u00E1ce ukazuj\u00EDc\u00ED na mo\u017Enost antigen.p\u016Fsoben\u00ED l\u00E1tek a indukce diabet.retinopatie."@cs . . "Therapeutic Vasculogenesis In Patients With Peripheral Artery Disease"@en . . . . "NR8047" . . " bone marrow blood" . "peripheral artery disease" . "Project dealing with popul.of patient with critical ischemia without possibility of revascularization.Outol. items cells were aplicated intraarteiatly"@en . . . . " vasculogenesis" . . . . . " mobilisation" . "1"^^ . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NR8047"^^ . "3"^^ . "3"^^ . . "0"^^ . " statins" . . "Terapeutick\u00E1 vaskulogeneze u pacient\u016F s ischemickou chorobou doln\u00EDch kon\u010Detin" . . "Celkem 60 pacient\u016F s kritickou isch\u00E9mi\u00ED doln\u00ED kon\u010Detiny bez mo\u017Enosti dal\u0161\u00ED revaskularizace bude randomizov\u00E1no do t\u0159\u00EDramenn\u00E9 studie. V prvn\u00EDm rameni budou pacienti l\u00E9\u010Deni standardn\u011B prostaglandinem E. Ve druh\u00E9m rameni bude prob\u00EDhat eskala\u010Dn\u00ED studie zam\u011B\u0159en\u00E1 na optim\u00E1ln\u00ED d\u00E1vku G-CSF a simvastatinu k mobilizaci endotelov\u00FDch prekurzor\u016F. Ve t\u0159et\u00EDm rameni bude pacient\u016Fm odebr\u00E1na kostn\u00ED krev a po zpracov\u00E1n\u00ED aplikov\u00E1na do posti\u017Een\u00E9 kon\u010Detiny. Prim\u00E1rn\u00EDm c\u00EDlem bude \u00FA\u010Dinnost a bezpe\u010Dnost experiment\u00E1ln\u00EDch metod terapie. Sekund\u00E1rn\u00EDm c\u00EDlem bude zji\u0161t\u011Bn\u00ED rozd\u00EDl\u016F mezi diabetiky a nediabetiky a stanoven\u00ED optim\u00E1ln\u00EDho pom\u011Bru jednotliv\u00FDch bun\u011B\u010Dn\u00FDch populac\u00ED pod\u00EDlej\u00EDc\u00EDch se na terapeutick\u00E9m efektu. Sledov\u00E1n bude \u00FAstup bolest\u00ED, zhojen\u00ED trofick\u00FDch efekt\u016F a doba do amputace kon\u010Detiny. Sou\u010D\u00E1st\u00ED projektu bude studie kvality \u017Eivota a ekonomick\u00E1 kalkulace." . . "Sixty patients with critical peripheral artery disease of the leg without further revascularization possibilities will be randomized into the three arm study. In the first arm, standard treatment with prostaglandin for four weeks will be given. In the second arm, an escalation study to determine the optimal dose of G-CSF and simvastatin for endothelial precursors mobilization will be performed. In the third arm, the processed autologous marrow blood will be applied into the ischemic leg artery. Primary endpoint will be safety and effectiveness of the experimental treatments. Secondary endpoints will be finding the difference between diabetics and nondiabetics and to determine the role of different cellular progenitors on the treatment effect. Evaluated will be the dissapearance of leg pain at rest, healing of ischemic defects and time to amputation. Quality-of-life study and economical calculation will be performed."@en . .