"1"^^ . "maternal milk" . "Study of immunological properties of colostrum and milk of healthy and allergic mothers. Relationship with newborn\u00B4s immunity"@en . . "0"^^ . . "maternal milk; breastfeeding; allergic mothers; newborn\u00B4s immunity; secretory antibodies; milk cytokines; milk cells; regulation of immunity"@en . . . . "http://www.isvav.cz/projectDetail.do?rowId=NR8040"^^ . . . . "5"^^ . . . "5"^^ . . . "Studium imunologick\u00FDch vlastnost\u00ED kolostra a ml\u00E9ka zdrav\u00FDch a alergick\u00FDch matek a jejich vztah k imunit\u011B novorozence" . " milk cytokines" . . " allergic mothers" . . " milk cells" . . . " secretory antibodies" . " breastfeeding" . "Composition of milk of healthy and allergic mothers will be compared. sIgA concentration and specific antibodies to common allergens in IgA and IgE classes will be tested. Cytokines, mainly that influencing Th1-Th2 equilibrium and IgA and IgE isotype switch will be followed. Milk cells (lymphocytes, macrophages and epithelial cells) will be characterized. Their effect and that of other milk constituents on stimulation of cord blood cells will be tested in vitro in cocultivation experiments. The correlation between milk composition and later development of allergy will be analyzed. The effect of breastfeeding by allergic mothers will be evaluated."@en . . . " newborn\u00B4s immunity" . "2007-08-08+02:00"^^ . . "Bude porovn\u00E1no slo\u017Een\u00ED ml\u00E9ka zdrav\u00FDch a alergick\u00FDch matek. Bude testov\u00E1na koncentrace sIgA, specifick\u00E9 protil\u00E1tky proti nej\u010Dast\u011Bj\u0161\u00EDm alergen\u016Fm v t\u0159\u00EDd\u00E1ch IgA a IgE a koncentrace cytokin\u016F,zejm\u00E9na t\u011Bch,kter\u00E9 ovliv\u0148uj\u00ED rovnov\u00E1hu Th1-Th2 a tvorbu IgA a IgE Budou charakterizov\u00E1ny bu\u0148ky ml\u00E9ka (lymfocyty, makrof\u00E1gy a epitelov\u00E9 bu\u0148ky) a v kokultiva\u010Dn\u00EDch pokusech bude sledov\u00E1no jejich p\u016Fsoben\u00ED a p\u016Fsoben\u00ED ostatn\u00EDch slo\u017Eek ml\u00E9ka na stimulaci bun\u011Bk pupe\u010Dn\u00EDkov\u00E9 krve. Bude analyzov\u00E1n vztah mezi slo\u017Een\u00EDm ml\u00E9ka a p\u0159\u00EDpadn\u00FDm pozd\u011Bj\u0161\u00EDm v\u00FDskytem alergick\u00FDch onemocn\u011Bn\u00ED u d\u011Bt\u00ED, zejm\u00E9na potravinov\u00E9 alergie a atopick\u00FDch ekz\u00E9m\u016F, kter\u00E9 se objevuj\u00ED u d\u011Bt\u00ED i \u010Dasn\u011B po narozen\u00ED." . "Differences between healty and allrergic mothers and their children were proved in cytokine and specific IgE productions and in features of colostral and cord blood cells. Results can be exploited for assessment of risk of future allergy manifestation."@en . "Mezi zdrav\u00FDmi a alergick\u00FDmi matkami a jejich d\u011Btmi byly zji\u0161t\u011Bny rozd\u00EDly v produkci cytokin\u016F a specifikace IgE a ve vlastnostech bun\u011Bk kolostra a bun\u011Bk pupe\u010Dn\u00EDkov\u00E9 krve. V\u00FDsledky jsou vyu\u017Eiteln\u00E9 pro posouzen\u00ED rizika budouc\u00EDho vzniku alergie."@cs . "NR8040" . "1"^^ .