. "1"^^ . "1"^^ . " DNA" . "2007-08-08+02:00"^^ . . . "Proposed project is focused on clinical study of inherited genetic polymorphisms and their association with prostate cancer for their potential application in preventive screening. Current as well as new prostate cancer patients will be registered together with controls. Their positivity or negativity will be confirmed with a set of examinations. Blood samples from each patient and control will be taken for genetic testing. SNP polymorphisms from genes involved in testosterone synthetic pathway (CYP17, CYP3A4, SRD5A2 and Androgen receptor gene) will be selected from public databases based on their association with prostate cancer from prior studies. Project is organized into several phases from initial indentification of potential marker candidates and optimalization of their analysis conditions till screening of the final marker set in 300 patients and 300 controls."@en . . " SNP" . . "Identifikace vrozen\u00FDch DNA polymorfism\u016F u skupiny gen\u016F syntetick\u00E9 dr\u00E1hy testosteronu jako faktor\u016F genetick\u00E9 predispozice pro vznik a v\u00FDvoj karcinomu prostaty a jejich vyu\u017Eit\u00ED pro prevenci a odhad progn\u00F3zy v \u010Desk\u00E9 populaci" . "Identification of inherited DNA polymorphisms in genes of testosterone synthetic pathway as factors of genetic predisposition to development of prostate cancer and their use in prevention and prognosis in Czech population"@en . " prevention" . "P\u0159edkl\u00E1dan\u00FD projekt je zam\u011B\u0159en na v\u00FDzkum vztahu (asociace) mezi skupinou vybran\u00FDch vrozen\u00FDch DNA polymorfism\u016F (SNP) a v\u00FDskytem n\u00E1doru prostaty a jeho n\u00E1sledn\u00E9 vyu\u017Eit\u00ED pro \u010Dasnou diagnostiku tohoto onemocn\u011Bn\u00ED. Sou\u010Dasn\u00ED a nov\u00ED pacienti budou registrov\u00E1ni spole\u010Dn\u011B s kontrolami. jejich positivita resp. negativita bude potvrzena kombinac\u00ED n\u011Bkolika vy\u0161et\u0159en\u00ED. Vzorky krve pro genetick\u00E9 testov\u00E1n\u00ED budou odebr\u00E1ny v\u0161em pacient\u016Fm a kontrol\u00E1m. SNP polymorfismy z gen\u016F syntetick\u00E9 dr\u00E1hy testosteronu (CYP17, CYP3A4, SRD5A2 a gen androgenn\u00EDho receptoru) budou vybr\u00E1ny z ve\u0159ejn\u011B p\u0159\u00EDstupn\u00FDch datab\u00E1z\u00ED na z\u00E1klad\u011B jejich asociace s n\u00E1dorem prostaty potvrzen\u00E9 v p\u0159edchoz\u00EDch studi\u00ED. Projekt je zpracov\u00E1n do n\u011Bkolika f\u00E1z\u00ED od identifikace potenci\u00E1ln\u00EDch genetick\u00FDch marker\u016F p\u0159es optimalizaci jejich zpracov\u00E1n\u00ED metodami PCR amplifikace a\u017E po klinickou studii zahrnuj\u00EDc\u00ED screening z\u00EDskan\u00E9 markerov\u00E9 sady u 300 pacient\u016F a 300 kontrol." . . "Identifikovali jsme polymorfismy genu SDR5A2, kter\u00E9 se zdaj\u00ED b\u00FDt prediktorem v\u00FDskytu karcinomu prostaty. Vy\u0161et\u0159en\u00ED SDR5A2 haplotyp\u016F by mohlo napomoci k \u010Dasn\u00E9 identifikaci rizikov\u00FDch skupin. U ostatn\u00EDch polymorfism\u016F asociace vysledov\u00E1na nebyla."@cs . " predisposition" . "prostate; cancer; prevention; predisposition; polymorphism; DNA; SNP; mutation"@en . . . " polymorphism" . . . "http://www.isvav.cz/projectDetail.do?rowId=NR8039"^^ . "We have identified SRD5A2 gene polymorphisms that appear to be predictors of prostate cancer incidence. Examination of SRD5A2 haplotypes could help in identification of risk groups. None of the other studied polymorphisms showed association with cancer."@en . . . "6"^^ . "6"^^ . . . . . . "prostate" . . "0"^^ . . "NR8039" . . " cancer" .