. "lung carcinoma" . . . "Inhibition of the MITF transcription factor activity by repressing its targets results in suppressed proliferation of melanoma cells in culture. CR1 region of the oncoprotein E1A is sufficient for repression of MITF activity."@en . . "Je navr\u017Eeno n\u011Bkolika nez\u00E1visl\u00FDmi molekul\u00E1rn\u00EDmi p\u0159\u00EDstupy studovat \u00FAlohu transkrip\u010Dn\u00EDho faktoru MITF v patogenezi malign\u00EDho melanomu a \u00FAlohu faktoru HASH1 v patogenezi malobun\u011B\u010Dn\u00E9ho karcinomu plic. Kvantitativn\u00ED ur\u010Den\u00ED hladiny MITF u melanomu m\u016F\u017Ee pomoci p\u0159i diagnoze a ur\u010Den\u00ED hladiny HASH1 p\u0159i progn\u00F3ze malobun\u011B\u010Dn\u00E9ho karcinomu plic." . " melanoma" . . "2"^^ . "2"^^ . "Inhibice funkce transkrip\u010Dn\u00EDho faktoru MITF blokov\u00E1n\u00EDm exprese jeho transkrip\u010Dn\u00EDch c\u00EDl\u016F m\u00E1 za n\u00E1sledek inhibici proliferace melanomov\u00FDch bun\u011Bk v kultu\u0159e. Oblast CR1 onkoproteinu E1A je posta\u010Duj\u00EDc\u00ED k represi funkce MITF."@cs . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NR8026"^^ . "1"^^ . . "0"^^ . "NR8026" . "2007-08-08+02:00"^^ . . "We propose to use multiple independent molecular approaches to elucidate the importance of the transcription factor MITF in the pathogenesis of human melanoma and the role of transcription factor HASH1 in small cell lung carcinoma. The quantitative estimation of MITF can also be helpful for the diagnosis of melanoma and HASH1 may help in prognostic consideration in small cell lung carcinoma."@en . " transcription" . . "Transcription factor MITF in melanoma and transcription factor HASH1 in small cell lung carcinoma: use in diagnosis and prognosis and their role in pathogenesis."@en . . . . . " MITF" . "Transkrip\u010Dn\u00ED faktory MITF u malign\u00EDho melanomu a HASH1 u malobun\u011B\u010Dn\u00E9ho karcinomu plic: Vyu\u017Eit\u00ED p\u0159i diagn\u00F3ze a progn\u00F3ze a \u00FAloha v patogenezi" . "lung carcinoma; melanoma; MITF; HASH1; transcription; apoptosis"@en . " HASH1" . . . . . . . .