"Hematopoetick\u00E9 kmenov\u00E9 bu\u0148ky krvetvorby se vyu\u017E\u00EDvaj\u00ED k obnov\u011B funkce kostn\u00ED d\u0159en\u011B p\u0159i transplantaci krvetvorby. Klinicky jsou definov\u00E1ny jako bu\u0148ky exprimuj\u00EDc\u00ED CD34+ antigen. CD34+ bu\u0148ky nejsou homogenn\u00ED, ale zahrnuj\u00ED jak pluripotentn\u00ED hematopoetick\u00E9 kmenov\u00E9 bu\u0148ky, tak i progenitory a prekursory lini\u00ED krvetvorby. Lze je charakterizovat pomoc\u00ED imunofenotypizace. D\u00E1vka CD34+ bun\u011Bk souvis\u00ED s dobou do p\u0159ihojen\u00ED u autologn\u00EDch transplantac\u00ED, av\u0161ak nemus\u00ED tomu tak b\u00FDt v alogenn\u00EDch podm\u00EDnk\u00E1ch. Obdob\u00ED posttransplanta\u010Dn\u00EDho \u00FAtlumu kostn\u00ED d\u0159en\u011B je kritick\u00E9 pro pacienta a p\u0159edtavuje riziko z\u00E1va\u017En\u00FDch komplikac\u00ED. Nalezen\u00ED souvislosti mezi zastoupen\u00EDm CD34+ subpopulac\u00ED a p\u0159ihojen\u00EDm transplant\u00E1tu by mohlo b\u00FDt p\u0159\u00EDnosem nejen pro diagnostiku, ale rovn\u011B\u017E potenci\u00E1ln\u011B pro terapii zejm\u00E9na v podm\u00EDnk\u00E1ch alogenn\u00ED transplantace krvetvorby." . . "hematopoietic cells" . "0"^^ . . "2"^^ . . "2"^^ . "Auto\u0159i studovali souvislost mezi d\u00E1vkou CD34+bun\u011Bk a rychlost\u00ED p\u0159ipojen\u00ED \u0161t\u011Bpu. Zat\u00EDmco d\u00E1vka CD34+ bun\u011Bk nejl\u00E9pe koreluje s rychlost\u00ED p\u0159ipojen\u00ED u nemyelobl. re\u017Eim\u016F, d\u00E1vka CD34+36+ bun\u011Bk je lep\u0161\u00ED prediktor p\u0159ipojen\u00ED u myeloablast.re\u017Eim\u016F."@cs . . "1"^^ . "Subpopulace CD34+ bun\u011Bk v transplant\u00E1tu perifern\u00EDch kmenov\u00FDch bun\u011Bk a jejich role pro engraftment v podm\u00EDnk\u00E1ch autologn\u00ED a p\u0159\u00EDbuzensk\u00E9 alogenn\u00ED transplantace krvetvorby v l\u00E9\u010Db\u011B n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED" . " flow cytometry" . . . " transplantation" . . . "Hematopoietic stem cells fully reconstitute the function of bone marrow after transplantation of hematopoiesis. They can be clinically defined as cells expressing CD34+ antigen. CD34+ cell population is not homogeneous, but it includes pluripotent hematopoietic stem cells, as well as progenitor and precursor cells of hematopoietic lineages. CD34+ cell subpopulations can be characterized by immunophenotyping. CD34+ dose correlates with time to engraftment in autologous transplantations, but it may not be so in allogeneic setting. Period of post-transplantational cytopenia presents a risk for serious, life-threatening complications. Discovery of the relation between CD34 subpopulations and engraftment of transplant could be a significant contribution not only for diagnostics, but also for new therapy approaches, especially under conditions of allogeneic transplantation."@en . "0"^^ . . . "Subpopulations of CD34 cells in peripheral blood stem cells graft and their role for engraftment in autologous and related-donor allogeneic transplantation of hematopoiesis in the treatment of cancer"@en . . . . . "2007-08-08+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NR8003"^^ . . . "NR8003" . "Authors confirmed that CD34+ cells content correlates with the speed of engraftment while CD34+ cells remain the best predictor of speed of engraftment after nonmyeloabl.regimens, the dose of CD34+36+appears to be better predictor after myeloabl.regim."@en . . . . "hematopoietic cells; transplantation; flow cytometry; CD34+ cells"@en .