"0"^^ . "4"^^ . "4"^^ . " Proliferation" . "Induction of processes blocking the proliferation of leukemic cells by inhibition of transcription of ribosomal genes."@en . "0"^^ . "A mechanismof the actinomycine D and to some extend of butyrate effect on normal blood lymphocyte was described."@en . "http://www.isvav.cz/projectDetail.do?rowId=NR7998"^^ . "A linkage between the antiproliferative and proapoptotic efect of therapeutic agents and down regulation of rRNA synthesis in leukemic cells will be studied by in-vestigation of nucleolar transcription factors expression, modification and integrity. Leukemic cell lines representing various states of haematopoetic differenti-ation and chemical and physical repressors of proliferation and inductors of program-med cell death will be used."@en . . . " Inhibition" . . . . . . . . . " UBF" . . "Indukce proces\u016F blokuj\u00EDc\u00EDch n\u00E1dorovou bun\u011B\u010Dnou proliferaci inhibic\u00ED ribozom\u00E1ln\u00ED synt\u00E9zy v nukleolech leukemick\u00FDch bun\u011Bk." . . . . . " Nucleolus" . "Leukaemia" . . . "Charakterizace, kvantifikace a bun\u011B\u010Dn\u00E1 selektivita antiproliferativn\u00EDch proces\u016F c\u00EDlen\u00FDch do nukleolu n\u00E1dorov\u00FDch bun\u011Bk bude studov\u00E1na zkoum\u00E1n\u00EDm zm\u011Bn exprese rRNA a ex-prese, modifikace a integrity proteinov\u00FDch faktor\u016F ribozom\u00E1ln\u00EDho transkrip\u010Dn\u00EDho apar\u00E1tu. Budou u\u017Eity bun\u011B\u010Dn\u00E9 modely reprezentovan\u00E9 leukemick\u00FDmi liniemi na r\u016Fzn\u00E9 \u00FArovni hematopoetick\u00E9 diferenciace. Represe proliferace a bun\u011B\u010Dn\u00E1 smrt bude navozena vn\u011Bj\u0161\u00EDmi efektory, zejm\u00E9na terapeuticky \u00FA\u010Dinn\u00FDmi \u010Dinidly." . "Leukaemia; rRNA; Nucleolus; UBF; SL1; Inhibition; Proliferation; Apoptosis"@en . "NR7998" . . "Popis mechanismu p\u016Fsoben\u00ED amktinomycinu D a \u010D\u00E1ste\u010Dn\u011B butyr\u00E1tu na norm\u00E1ln\u00ED lymfocyty perifern\u00ED krve."@cs . . "2007-08-08+02:00"^^ . " SL1" . "1"^^ . " rRNA" .