. " genotyping" . . . . . "Project confirmed high level of mismatches of HLA-DPB1 gene between patients and their HSC donors. The search for match in HLA_DPB1 locus is not acceptable. The method of direct sequencing for HLA typing was implemented to the standard search protocol."@en . "Retrospective study: Exactly defined mismatches between an unrelated donor and the recipient of HSC in HLA-DP and HLA-A, -B, -C, -DRB1, -DQB1 will be evaluated with different parameters of the transplantation outcome. Perspectives: The standard protocol for suitable unrelated HSC donor search will be modified: SBT will be implemented for HLA genotyping and on the specific conditions HLA-DPB1 will be typed to search the best donor."@en . "HSCT" . " HLA complex" . "Studium vlivu HLA-DP gen\u016F na transplantace hematopoetick\u00FDch kmenov\u00FDch bun\u011Bk (HSCT). Porovn\u00E1n\u00ED neshod mezi pacientem a nep\u0159\u00EDbuzn\u00FDm d\u00E1rcem v HLA-DP s parametry \u00FAsp\u011B\u0161nosti transplantace. \u00DAprava standardn\u00EDho protokolu vyhled\u00E1v\u00E1n\u00ED nep\u0159\u00EDbuzn\u00FDch d\u00E1rc\u016F HSC: zaveden\u00ED metody Sequence-Based Typing, v indikovan\u00FDch p\u0159\u00EDpadech rutinn\u00ED genotypizace HLA-DP touto metodou." . "0"^^ . "An effect of HLA-DP incompatibilities on the outcome of hematopoietic stem cell transplantation."@en . "2007-08-08+02:00"^^ . "1"^^ . " allele match/mismatch" . . "Vliv inkompatibilit v DP genech na \u00FAsp\u011Bch transplantac\u00ED hematopoetick\u00FDch kmenov\u00FDch bun\u011Bk" . . "Studie prok\u00E1zala vysokou m\u00EDru neshod HLA-DPB1 genu mezi pacienty a d\u00E1rci HSC, proto nen\u00ED \u00FA\u010Deln\u00E9 roz\u0161\u00ED\u0159en\u00ED po\u017Eadavku shody i na tento lokus. Pro zv\u00FD\u0161en\u00ED p\u0159esnosti HLA test\u016F byla zavedena metoda p\u0159\u00EDm\u00E9 sekvenace do standardn\u00EDho protokolu v\u00FDb\u011Bru d\u00E1rc\u016F."@cs . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NR7984"^^ . . "8"^^ . "8"^^ . "NR7984" . . . . . . " Sequence-Based Typing" . . . . . . . " HLA-DP" . "HSCT; HLA complex; HLA-DP; genotyping; Sequence-Based Typing; allele match/mismatch; transplantation outcome"@en .