"0"^^ . "Obesita p\u0159edstavuje v\u00FDznamn\u00FD rizikov\u00FD faktor po transplantaci ledviny. Jedn\u00E1 se o obezitu viscer\u00E1ln\u00EDho typu u mu\u017E\u016F i \u017Een jej\u00ED\u017E prevalence \u010Din\u00ED 25-35 % v prvn\u00EDm roce po transplantaci (BMI > 27 kg/m2). Obesita je spojena s metabolick\u00FDmi komplikacemi (hyperlipidemie, hyperhomocysteinemie,hyperleptinemie,zv\u00FD\u0161en\u00E1 hladina AGEs),kter\u00E9 spolu s hypertenz\u00ED a dlouhodob\u00FDm pod\u00E1v\u00E1n\u00EDm imunosupresivn\u00EDch l\u00E9k\u016F vedou k endotel.dysfunkci a kardiovask. komplikac\u00EDm. Obezita se v\u00FDznamn\u011B pod\u00EDl\u00ED na \u010Dasn\u00FDch i dlouhodob\u00FDch chirurgick\u00FDch komplikac\u00EDch a m\u016F\u017Ee ovlivnit i chronickou rejekci. K posouzen\u00ED p\u0159esn\u00E9 funkce transplantovan\u00E9 ledviny je t\u0159eba pou\u017E\u00EDt novou metodu s p\u0159epo\u010Dtem na tukuprostou tk\u00E1\u0148 (lean body mass). Nutri\u010Dn\u00ED p\u00E9\u010De o ob\u00E9zn\u00ED nemocn\u00E9 vy\u017Eaduje \u010Dasnou detekci, edukaci a vypracov\u00E1n\u00ED indivializovan\u00E9 hypoenergetick\u00E9 diety s dobrou adherenc\u00ED. Sou\u010Dasn\u00E1 farmakoterapie spojen\u00E1 s \u00FApravou imunosupresivn\u00ED l\u00E9\u010Dby p\u0159\u00EDmo ovlivn\u00ED i p\u0159idru\u017Een\u00E9 metabolick\u00E9 poruchy." . "1"^^ . " hyperleptinemia" . . "Obesity is a major risk factor after renal transplantation. The prevalence of visceral obesity (BMI > 27 kg/m2) in men and women in the first post-transplant year is 25-35%. Obesity associated with metabol.complications, hypertension and long-term administration of immunosuppressive agents can result in endothelial dysfuntion and cardiovascular complications. Obesity plays a major role in early and late surgical complications and may even have an effect on chronic rejection. A new method with respect to lean body mass has to be used to exactly evaluate renal graft function. Nutrition management requires early detection and development of an individual low energy diet with good adherence.Concomitant pharmacotherapy combined with immunosupp.therapy adjustment will also have a direct effect on metab.disorders."@en . " hyperlipidemia" . . . . " endothelial dysfunction" . . "0"^^ . . "2007-08-08+02:00"^^ . . "The project evaluated some new aspect in metabolism of patients after kidney transplantations."@en . " hyperhomocysteinemia" . . . . . "NR7865" . "Obezita po transplantaci ledviny, jej\u00ED dynamika a metabolick\u00E9 komplikace" . "OBESITY AFTER RENAL TRANSPLANTATION, ITS DYNAMICS AND METABOLIC COMPLICATIONS"@en . . "http://www.isvav.cz/projectDetail.do?rowId=NR7865"^^ . . . . " obesity" . . " surgical complications" . . "13"^^ . "renal transpl." . "renal transpl.; obesity; hyperlipidemia; hyperhomocysteinemia; hyperleptinemia; surgical complications; endothelial dysfunction; chronic rejection"@en . "13"^^ . . "Projekt p\u0159inesl nov\u00E9 poznatky v oblasti metabolizmu nemocn\u00FDch po transplantaci ledviny."@cs . .