. . "selenium" . "NR7820" . "2007-06-30+02:00"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=NR7820"^^ . "2008-09-16+02:00"^^ . . . "Deficiency of selenium proved in the \u010CR may worsen health estate of the population by increase of frequency of %22oxidative%22 diseases as well as infectious diseases through decrease of GPx activity - increase of Se intake might eliminate this hasard. Antioxidative activity of pGPx and oxidative load by the analysis of MDA will be analysed during the long-lasting supplementation by various amounts and species of Se. Health estate of persons with and without Se will be monitored and confronted. Selenoenzymes play a role in many pathways - other essential elements (Zn,Fe,I), thyroid hormones, lipids, and thiols including homocysteine (that is said to increase various health hazards and oxidative stress) will be analysed during Se intervention. Cognitive functions will be detected at the start and at the end of the study and confronted among the groups according Se quantum and Se species used for the supplementation."@en . "3"^^ . "0"^^ . "3"^^ . "1"^^ . . " pGPx" . " malondialdehyd" . "0"^^ . "Nedostatek selenu nalezen\u00FD u obyvatel \u010CR m\u016F\u017Ee zhor\u0161it zdravotn\u00ED stav populace zv\u00FD\u0161en\u00EDm %22oxidativn\u00EDch%22 i infek\u010Dn\u00EDch onemocn\u011Bn\u00ED sn\u00ED\u017Een\u00EDm antioxidativn\u00ED ochrany organismu selenoenzymy peroxid\u00E1zami (GPx) - zv\u00FD\u0161en\u00ED p\u0159\u00EDjmu Se m\u016F\u017Ee toto nebezpe\u010D\u00ED eliminovat. V pr\u016Fb\u011Bhu dlouhodob\u00E9 suplementace r\u016Fzn\u00FDmi d\u00E1vkami a slou\u010Deninami Se bude sledov\u00E1na antioxidativn\u00ED aktivita pGPx a oxidativn\u00ED zat\u00ED\u017Een\u00ED anal\u00FDzami MDA. V pr\u016Fb\u011Bhu intervence Se bude sledov\u00E1n a porovn\u00E1v\u00E1n zdravotn\u00ED stav proband\u016F s a bez suplementace Se. Selenoenzymy maj\u00ED vliv na mnoho reakc\u00ED - v pr\u016Fb\u011Bhu suplementace Se budou sledov\u00E1ny dal\u0161\u00ED esenci\u00E1ln\u00ED prvky (Zn,Fe,I), thyroide\u00E1ln\u00ED hormony, lipidy a thioly v\u010Detn\u011B homocysteinu, spojovan\u00E9ho s mnoha zdravotn\u00EDmi riziky a zvy\u0161uj\u00EDc\u00EDho oxidativn\u00ED z\u00E1t\u011B\u017E. Na za\u010D\u00E1tku a na konci studie budou m\u011B\u0159eny a porovn\u00E1v\u00E1ny mezi skupinami senior\u016F se suplementac\u00ED a bez suplementace Se kognitivn\u00ED funkce. U v\u0161ech sledovan\u00FDch parametr\u016F bude porovn\u00E1v\u00E1n vliv r\u016Fzn\u00FDch d\u00E1vek a r\u016Fzn\u00FDch slou\u010Denin Se, pou\u017Eit\u00FDch na suplementaci." . "selenium; supplementation; state of health; pGPx; essential elements; thyroid hormones; malondialdehyd; homocysteine"@en . . . . " essential elements" . " supplementation" . " state of health" . . . " thyroid hormones" . . . "2004-01-01+01:00"^^ . "Mimo\u0159\u00E1dn\u00FD p\u0159\u00EDnos v\u00FDsledk\u016F, kter\u00E9 by m\u011Bly b\u00FDt vyu\u017Eity k zlep\u0161en\u00ED zdrav.stavu nejen senior\u016F, kde byl prok\u00E1z\u00E1n t.\u010D. Se deficit nejv\u011Bt\u0161\u00ED, ale pro celou na\u0161i populaci zaveden\u00EDm \u0161irok\u00E9 profylaxe Se nedostatku."@cs . . "Exceptional contribution of results, which should have been used for improvement of health conditions of not only elderly people, where Se deficit was shown higher, but for the whole population by the implementation of broad prophylaxes of Se shortage"@en . "Changes of selected metabolites in the course of optimalization of selenium in the organism"@en . . . "Sledov\u00E1n\u00ED zm\u011Bn vybran\u00FDch metabolit\u016F v pr\u016Fb\u011Bhu optimalizace stavu selenu v organismu" . .