"2007-08-08+02:00"^^ . . . . "fetal DNA; apoptosis; prenatal diagnosis; capillary electrophoresis; aneuploidy"@en . "NR7817" . "Concentration dynamics of apoptic and extracellular fetal DNA in maternal plasma during the gravidity and after birth (delivery) and directed DNA analysis of ploidies in normal and pathological gravidity"@en . . . "C\u00EDlen\u011B kvantifikovat a charakterizovat extracelul\u00E1rn\u00ED fet\u00E1ln\u00ED DNA v maternaln\u00EDm s\u00E9ru s vyu\u017Eit\u00EDm inovovan\u00E9 techniky QF PCR v pr\u016Fb\u011Bhu t\u011Bhotenstv\u00ED a kr\u00E1tce po n\u011Bm u norm\u00E1ln\u00EDch a patologick\u00FDch gravidit a statisticky posoudit v\u00FDsledky. Rozpoznat a molekul\u00E1rn\u011B - cytogeneticky analyzovat fet\u00E1ln\u00ED apoptickou DNA v pr\u016Fb\u011Bhu t\u011Bhotenstv\u00ED u norm\u00E1ln\u00EDch a patologick\u00FDch gravidit a statisticky vyhodnotit a porovnat oba soubory." . . "Project established a method for evaluation of free fetal DNA in maternal plasma using capillary electrophoresis, created calibration curve of free fetal DNA during physiological pregnancy a described high amount of free fetal DNA in Down syndrome."@en . . . "12"^^ . . "12"^^ . . . . . . . . " capillary electrophoresis" . "0"^^ . "Dynamika koncentrace apoptick\u00E9 a extracelul\u00E1rn\u00ED fet\u00E1ln\u00ED DNA v matern\u00E1ln\u00ED plazm\u011B (s\u00E9ru) v pr\u016Fb\u011Bhu t\u011Bhotenstv\u00ED a po porodu a c\u00EDlen\u00E1 DNA anal\u00FDza ploidie u norm\u00E1ln\u00EDch a patologick\u00FDch gravidit." . " prenatal diagnosis" . "fetal DNA" . "1"^^ . . "1"^^ . " apoptosis" . "http://www.isvav.cz/projectDetail.do?rowId=NR7817"^^ . . "To do proper quantification and characterization of extra-cellular fetal DNA in maternal serum and use innovated technique of QF PCR during pregnancy and after delivery in normal and pathological pregnancies and statistical evaluation of the results. Identification of fetal apoptic DNA, and its analyses with molecular-cytogenetic methods in normal and pathologic pregnancies. Statistical evaluation and comparison of both sets."@en . . . "Zavedena metoda hodnocen\u00ED voln\u00E9 fet\u00E1ln\u00ED DNA v matern\u00E1ln\u00ED plazm\u011B pomoc\u00ED kapil\u00E1rn\u00ED elektrofor\u00E9zy, navr\u017Eena kalibra\u010Dn\u00ED k\u0159ivka voln\u00E9 fet\u00E1jn\u00ED DNA b\u011Bhem fysiologick\u00E9 gravidity a zji\u0161t\u011Bn n\u00E1r\u016Fst voln\u00E9 fet\u00E1ln\u00ED DNA u Downova syndromu."@cs .