"-Oxygenated steroids as immunomodulators and thermogenic factors"@en . . " thyreopathies" . . "DHEA" . " 7-oxo-DHEA" . . " 7-OH-DHEA" . . . " thermogenesis" . " obesity" . . . "7-Oxygenovan\u00E9 steroidy jako imunomodul\u00E1tory a termogenn\u00ED faktory" . "Zji\u0161\u0165ov\u00E1ny zm\u011Bny koncentrac\u00ED 7-OH-metabolit\u016F DHEA ve st\u00E1\u0159\u00ED,dopad pod\u00E1v\u00E1n\u00ED 7-oxo-DHEA a konzumace sojov\u00FDch fytoestrogen\u016F na ukazatele tyreoid\u00E1ln\u00EDch fc\u00ED,vypracov\u00E1ny nov\u00E9 RIA met. ke stanoven\u00ED 7-oxo-a 16 -OH-DHEA a stanoveny jejich fyziolog.hladiny."@cs . . . . . "9"^^ . "9"^^ . "NR7815" . "1"^^ . . . . " autoimmunity" . "The levels of 7-hydroxylated DHEA metabolites will be followed up in patients with autoimmune endocrinopathies and in those treated with glucocorticoids. Investigation of 7-OH-DHEA should thus serve as an independent marker of autoimmune processes. 7-Oxo-DHEA, known to act as thermogenic factor, will be investigated in patients with impaired thermogenesis as in thyreopathies and in obese subjects. A method for determination of 7-oxo-DHEA will be developed and used for its mapping in population."@en . . . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NR7815"^^ . "Changes of 7-OH-DHEA metabolitites with aging,impact of 7-oxoDHEA admin.and consumption of soy phytoestrogens in thyroid param.were evaluated,novel RIA met.for 7-oxo- +16OH-DHEA analyses were developed;physiological levels of 7-oxo-+16OH-DHEA were determ"@en . . "Hladiny 7-hydroxylovan\u00FDch metabolit\u016F DHEA budou sledov\u00E1ny u soubor\u016F nemocn\u00FDch s autoimunitn\u00EDmi endokrinopatiemi a u nemocn\u00FDch l\u00E9\u010Den\u00FDch glukokortikoidy. Vy\u0161et\u0159en\u00ED 7-OH-DHEA by tak slou\u017Eilo jako nez\u00E1visl\u00FD ukazatel rozvoje autoimunitn\u00EDch pochod\u016F. Hladiny 7-oxo-DHEA, pova\u017Eovan\u00E9ho za termogenn\u00ED faktor, budou vy\u0161et\u0159eny u soubor\u016F nemocn\u00FDch s poruchami termogeneze - u tyreopati\u00ED a u ob\u00E9zn\u00EDch. Pro tyto \u00FA\u010Dely bude vyvinuta origin\u00E1ln\u00ED metoda a zmapov\u00E1ny hladiny tohoto steroidu v populaci." . "0"^^ . . . "2007-08-08+02:00"^^ . "DHEA; 7-OH-DHEA; 7-oxo-DHEA; autoimmunity; thyreopathies; thermogenesis; obesity; antiglucocorticoids"@en .