. . . . " fibrosis" . "Poru\u0161en\u00ED sign\u00E1ln\u00EDch drah regulovan\u00FDch/aktivovan\u00FDch interferonem (Jak-Stat, ERK1/2, NF-kB, MAP, atd.) resp. po\u0161kozen\u00ED \u010Di inhibice funkce p\u0159\u00EDslu\u0161n\u00FDch protein\u016F vlivem infekce HCV mohou zp\u016Fsobit rezistenci na l\u00E9\u010Dbu IFN alfa. Infekce HCV m\u016F\u017Ee zp\u016Fsobit alteraci exprese protein\u016F pod\u00EDlej\u00EDc\u00EDch se na procesu z\u00E1n\u011Btu a na procesu potla\u010Den\u00ED fibrogeneze (RXR, PPAR alfa, TGF beta 1, NF-kB, APO2, atd.). Anal\u00FDza prediktivn\u00EDhio v\u00FDznamu exprese uveden\u00FDch protein\u016F a stupn\u011B fibr\u00F3zy jatern\u00ED tk\u00E1n\u011B pro ur\u010Den\u00ED rezistence na l\u00E9\u010Dbu IFN alfa." . " interferon" . . . . . . " treatment" . . "NR7814" . . "V\u00FDsledky sice nedos\u00E1hly statistick\u00E9 v\u00FDznamnosti, ale p\u0159esto ukazuj\u00ED, \u017Ee proteiny rodiny STAT a jejich inhibitory z rodiny SOCS se pravd\u011Bpodobn\u011B mohou pod\u00EDlet na regulaci odpov\u011Bdi na l\u00E9\u010Dbu infekce HCV."@cs . "http://www.isvav.cz/projectDetail.do?rowId=NR7814"^^ . . "hepatitis C" . "Imunohistochemick\u00E1 detekce prediktivn\u00EDch faktor\u016F odpov\u011Bdi na l\u00E9\u010Dbu interferonem u pacient\u016F s chronickou hepatitis C." . . . . "3"^^ . "0"^^ . "Immunohistochemical detection of predictive factors of response to interferon therapy in patients with chronic hepatitis C"@en . "The results only approximated stasistical significance, but proteins of STAT family and their inhibitors SOCS and PIAS probably play an important regulatory role during response to treatment of chronic HC."@en . "3"^^ . "1"^^ . . " prediction" . . . . . "Hepatitis C virus (HCV) related alteration of signalling pathways and proteins (Jak-Stat, ERK1/2, NF-kB, MAP, etc.) regulated/activated by interferon (IFN) may lead to resistance to IFN treatment of patients with HCV infection. HCV infection may cause alteration of expression of proteins related to process of inflammation and to process of inhibion of fibrogenesis (RXR, PPAR alpha, TGF beta 1, NF-kB, APO2, etc.) Analysis of significance of expression of these studied proteins and significance of staging of fibrosis in liver tissue of HCV patients for prediction of resistance to IFN treatment."@en . "0"^^ . . "2007-08-08+02:00"^^ . "hepatitis C; fibrosis; treatment; interferon; prediction; immunohistochemistry"@en .