"0"^^ . . . . . . . "time series" . . "1"^^ . "1"^^ . "2"^^ . "Design of a Computer Module for Information Analysis of Time Series of Autonomous Protein System Responses (MIAPS)"@en . . "2"^^ . . . "protein expression;two-dimen.gel electrophoresis;CDK-inhibitor;time series;multidimensional analysis;tabular funtion derivatives;multidimes.statistical tests;bionics"@en . "Biologick\u00FD syst\u00E9m: %22tk\u00E1\u0148, bun\u011B\u010Dn\u00E1 kultura, bakteri\u00E1ln\u00ED suspenze apod.%22 je podroben vstupn\u00EDmu biologick\u00E9mu sign\u00E1lu: %22karcerogeny, ionizuj\u00EDc\u00ED nebo UV z\u00E1\u0159en\u00ED, xenobiotika, l\u00E9ky, stresov\u00E9 sign\u00E1ly, regul\u00E1tory bun\u011B\u010Dn\u00E9ho cyklu apod.%22. Odezvou jsou relativn\u00ED zm\u011Bny (mno\u017Estv\u00ED toho kter\u00E9ho proteinu v jednotk\u00E1ch po\u010D\u00EDta\u010Dov\u00E9 density) v proteinov\u00FDch map\u00E1ch (dvourozm.gelov\u00FDch elektroforetogramech) prom\u011B\u0159ovan\u00E9 v r\u016Fzn\u00FDch \u010Dasov\u00FDch intervalech po uskute\u010Dn\u011Bn\u00ED biologick\u00E9ho sign\u00E1lu. Pomoc\u00ED metody MDTSA (prog.MIAPS) bude mo\u017En\u00E9 studovat intimn\u00ED mechanismy biologick\u00FDch proces\u016F odehr\u00E1vaj\u00EDc\u00EDch se v biologick\u00E9m syst\u00E9mu(nap\u0159.): %22Vliv inhibitor\u016F CDK na spektrum protein\u016F v n\u00E1dorov\u00FDch bu\u0148k\u00E1ch%22. Za \u00FA\u010Delem v\u00FD\u0161e zm\u00EDn\u011Bn\u00E9 informa\u010Dn\u00ED anal\u00FDzy bude nezbytn\u00E9 stanovit a realizovat (naprogramovat a u\u017Eivatelsky zp\u0159\u00EDstupnit) n\u011Bkter\u00E9 speci\u00E1ln\u00ED matematicko-statistick\u00E9 algoritmy." . "multidimes.statistical tests" . "Po\u010D\u00EDta\u010Dov\u00FD modul pro informa\u010Dn\u00ED anal\u00FDzu \u010Dasov\u00FDch \u0159ad odezev autonomn\u00EDch proteinov\u00FDch syst\u00E9m\u016F."@cs . . "2005-09-23+02:00"^^ . . "two-dimen.gel electrophoresis" . "multidimensional analysis" . "http://www.isvav.cz/projectDetail.do?rowId=NO6458"^^ . "tabular funtion derivatives" . "protein expression" . "N\u00E1vrh po\u010D\u00EDta\u010Dov\u00E9ho Modulu pro Informa\u010Dn\u00ED Anal\u00FDzu \u010Dasov\u00FDch \u0159ad odezev autonomn\u00EDch Proteinov\u00FDch Syst\u00E9m\u016F (MIAPS)" . "Biological system:%22tissue, celular culture, bacterial suspension etc.%22 will be subjected to the initial biological signal: %22cancerogenes, ionizing or UV radiotion, xenobiotics,medicaments, stress signals,regulators of cellular cycle etc.%22. The response are relative changes (amount of particular protein in the units of computer density) on protein maps (two-dimensional gel electrophoretograms) measured in different time intervals after the beginning of the biological signal. It will be possible with the help of MDTSA to study and quantitatively estimate the intimate mechanism of biol. actions and processes taking place in the biol. system being studied: %22CKD-inhibitors influence on protein spectrum in tumour cells%22. For the purposes of the above mentioned information analysis it will be necessary to determine and to implement (programme and to make accessible for users some special mathematical statistical algorithmus."@en . . . . . "CDK-inhibitor" . "NO6458" . .