"NL7682" . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NL7682"^^ . . "0"^^ . "Ovlivn\u011Bn\u00ED akutn\u00ED a chronick\u00E9 poopera\u010Dn\u00ED bolesti preemptivn\u011B podan\u00FDm ketaminem" . . "acute postoperative pain;chronic;preemptive analgesia;NMDA receptror antagonists;ketamine"@en . . "chronic" . "6"^^ . . . "6"^^ . "acute postoperative pain" . "We intend to demonstrate that low-dose ketamine administered in perioperative period attenuates acute postoperative pain and prevents the development of a chronic postoperative pain. The NMDA receptor antagonist ketamine (o,5 mg. kg - 1 i.v.) administered before surgical stimuli and continued in low dose (1,0 mg.kg-1 per day) for 48 hours after surgery will significantly reduce acute postoperative pain and postmastectomy syndrome. The significance of the project is in a theoretical level in understanding our knowledge in pain modulation, in a practical level in improvement strategy in pain therapy for women aftermastectomy ( incidence approximately 4500 per year)."@en . . . "2006-06-23+02:00"^^ . . . . . "Preemptive and postoperative low-dose ketamine improves postoperative analgesia without side effects, decreases dose and side effects of opioids and has trend in decreased incidence of permanent and intensive chronic pain after breast cancer surgery."@en . . "C\u00EDlem na\u0161eho projektu je prok\u00E1zat, \u017Ee ketamin, blok\u00E1tor NMDA receptor\u016F, podan\u00FD p\u0159ed za\u010D\u00E1tkem operace a v poopera\u010Dn\u00EDm pr\u016Fb\u011Bhu v subanalgetick\u00FDch d\u00E1vk\u00E1ch vede k sn\u00ED\u017Een\u00ED akutn\u00ED poopera\u010Dn\u00ED i chronick\u00E9 bolesti po operaci prsu. V\u00FDsledn\u00FD p\u0159\u00EDnos projektu je jednak ve zlep\u0161en\u00ED na\u0161ich znalost\u00ED o modulaci bolesti a l\u00E9kov\u00E9 interakci, jednak ve zlep\u0161en\u00ED kvality \u017Eivota \u017Een operovan\u00FDch pro zhoubn\u00FD n\u00E1dor prsu ( incidence p\u0159es 4500 pacientek ro\u010Dn\u011B)." . "Preemptivn\u00ED a poopera\u010Dn\u00ED mal\u00E9 d\u00E1vky ketaminu nemaj\u00ED vedlej\u0161\u00ED \u00FA\u010Dinky a sni\u017Euj\u00ED d\u00E1vku i vedlej\u0161\u00ED \u00FA\u010Dinky poopera\u010Dn\u00EDch opioid\u016F, potla\u010Duj\u00ED poopera\u010Dn\u00ED bolest a vykazuj\u00ED trend ke sn\u00ED\u017Een\u00ED v\u00FDskytu trval\u00E9 a intenzivn\u00ED chronick\u00E9 bolesti po operaci rakoviny prsu."@cs . . . . . "The Effect of NMDA Receptor Antagonist Ketamine on Acute and Chronic Postoperative Pain"@en . "0"^^ . . . "preemptive analgesia" . . "NMDA receptror antagonists" .