"Preclinical testing of antioxidants were achieved in ischemia-reperfusion of laboratory rat kidney. Laboratory parameters were monitored and histopathology analyses were performed. It was achieved a determination of basic pharmacokinetic parameters."@en . "33"^^ . . . . "0"^^ . "pre-clinical testing" . "33"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=NL7455"^^ . . "Preklinick\u00E9 testov\u00E1n\u00ED z\u00E1vislosti \u00FA\u010Dinku na d\u00E1vce u l\u00E1tek s antioxida\u010Dn\u00EDm \u00FA\u010Dinkem za um\u011Ble navozen\u00E9ho patologick\u00E9ho stavu ischemie-reperfuze ledvinn\u00E9 tk\u00E1n\u011B. Testov\u00E1ny budou p\u0159\u00EDrodn\u00ED a syntetick\u00E9 l\u00E1tky. U laboratorn\u00EDch zv\u00ED\u0159at sledov\u00E1n\u00ED vybran\u00FDch parametr\u016F v t\u011Bln\u00EDch tekutin\u00E1ch a histopatologick\u00E9 vy\u0161et\u0159en\u00ED odebran\u00FDch org\u00E1n\u016F. Vliv l\u00E1tek na pr\u016Fb\u011Bh patologick\u00E9ho stavu. D\u00E1le stanoven\u00ED z\u00E1kladn\u00EDch farmakokinetick\u00FDch parametr\u016F na zdrav\u00FDch experiment\u00E1ln\u00EDch zv\u00ED\u0159atech po jednor\u00E1zov\u00E9 aplikaci l\u00E1tky. Sledov\u00E1n\u00ED hladin l\u00E1tky ve vzorc\u00EDch plazmy a sestaven\u00ED k\u0159ivky z\u00E1vislosti koncentrace na \u010Dase." . "1"^^ . "Sledov\u00E1n\u00ED z\u00E1vislosti \u00FA\u010Dinku na d\u00E1vce a z\u00E1kladn\u00EDch farmakokinetick\u00FDch parametr\u016F u origin\u00E1ln\u00EDch l\u00E1tek s antioxida\u010Dn\u00EDm \u00FA\u010Dinkem" . . . . . . . . "ischaemia-reperfusion" . "pharmacokinetic parameters" . "NL7455" . . . . "2006-06-23+02:00"^^ . . "Preclinical testing of the dependence of effect on dose in substances with antioxidative effect in artificially induced pathological condition of kidney tissue ischaemia-reperfusion. Natural and synthetic substances will be tested. Monitoring of selected parameters in body liquids and histopathology analysis of taken organs of laboratory animals. Influence of the substances on the development of pathological condition. Next, determination of basic pharmacokinetic parameters in healthy experimental animals after a single application of the substance. Monitoring of the substance level in plasma samples and construction of curve of dependence of concentration on time."@en . "Provedeno preklinick\u00E9 testov\u00E1n\u00ED l\u00E1tek s antioxida\u010Dn\u00EDm \u00FA\u010Dinkem u ischemie-reperfuze ledviny laboratorn\u00EDho potkana. Byly sledov\u00E1ny laboratorn\u00ED parametry a provedeno histopatologick\u00E9 vy\u0161et\u0159en\u00ED. Byly stanoveny z\u00E1kladn\u00ED farmakokinetick\u00E9 parametry."@cs . . . "Monitoring of the Dependence of Effect on Dose and of Basic Pharmacokinetic Parameters in Original Substances with Antioxidative Effect"@en . . "pre-clinical testing;ischaemia-reperfusion;pharmacokinetic parameters;antioxidants"@en . "0"^^ .