. . . . "http://www.isvav.cz/projectDetail.do?rowId=NL7073"^^ . "pharmacokinetic" . . "tramadol" . . "polymorphism" . . . "0"^^ . "Influence of CYP2D6 genetic polymorphism on disposition, therapeutic and side effects of tramadol in man"@en . . . "The given objectives were fulfilled. The contribution of this project is mainly the detection of phenotype CYP2D6 by pupilometry. And also the connection between those obtained pharmacokinetic parameters and genotype CYP2D6."@en . "1"^^ . . "2005-07-18+02:00"^^ . "Bude zhodnocen vliv polymorfizmu metabolizmu tramadolu na jeho p\u016Fsoben\u00ED po opakovan\u00E9m pod\u00E1v\u00E1n\u00ED u pacient\u016F po mal\u00E9m chirurgick\u00E9m v\u00FDkonu. Terapeutick\u00E9 p\u016Fsoben\u00ED, ne\u017E\u00E1douc\u00ED \u00FA\u010Dinky a podan\u00E9 d\u00E1vky budou sledov\u00E1ny ve vztahu k aktivit\u011B CYP2D6. Budou z\u00EDsk\u00E1ny poznatky o m\u00ED\u0159e ovlivn\u011Bn\u00ED farmakokinetick\u00FDch parametr\u016F tramadolu geneticky podm\u00EDn\u011Bn\u00FDmi zm\u011Bnami metabolizmu l\u00E9\u010Diva ve skupin\u011B zdrav\u00FDch dobrovoln\u00EDk\u016F. V\u00FDsledky budou pou\u017Eity k posouzen\u00ED mo\u017Enost\u00ED individualizace terapie tramadolem, zlep\u0161en\u00ED kvality \u017Eivota nemocn\u00FDch a sn\u00ED\u017Een\u00ED n\u00E1klad\u016F na lo\u010Dbu." . "2"^^ . "0"^^ . . "2"^^ . . "genotype" . . "adverse effect" . . "Anotovan\u00E9 c\u00EDle byly spln\u011Bny. P\u0159\u00EDnosem projektu je zji\u0161\u0165ov\u00E1n\u00ED fenotypu CYP2D6 pomoc\u00ED pupilometrie a souvislost takto z\u00EDskan\u00FDch farmakokinetick\u00FDch parametr\u016F s genotypem CYP2D6."@cs . . "Influence of the polymorpism of metabolism on the effects of tramadol will be studied after repeated administration in patients after minor surgery. Therapeutic, toxic effects and the dosage of tramadol will be evaluated in relation to CYP2D6 activity. The influence of genetically determined polymorphism of CYP2D6 on pharmacokinetic changes of tramadol will be evaluated in a group of healthy volunteers. Obtained results will show the possibilities of individualization of analgesic therapy by tramadol, improving patient\u00B4s quality of life and lowering costs."@en . "CYP2D6" . "NL7073" . "CYP2D6;polymorphism;tramadol;pharmacokinetic;adverse effect;genotype;phenotype"@en . . . . "Vliv geneticky podm\u00EDn\u011Bn\u00E9ho polymorfizmu CYP2D6 na osud, terapeutick\u00E9 p\u016Fsoben\u00ED a v\u00FDskyt ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F tramadolu u \u010Dlov\u011Bka." .