. . . . . "Use of exhaled condensate as a source of a variety of markers and mediators is based on the hypothesis that aerosol partickles exhaled in human breath reflect the composition of the bronchoalveolar extracellular lining fluid. Biomarkers and mediators such as leukotrienes, nitrites/nitrates, nitrotyrosine ets. reflect the changes caused by oxidative damage and iflammation, and may be therefore valuable in monitoring of airway inflammation in patients with bronchial asthma. The aim of this project is to assess the value of the breath condensate analysis as a noninvasive method in establishing the diagnosis of bronchial asthma and monitoring the level of achieved asthma control in children."@en . "biomarkers of inflammation" . "0"^^ . "asthma;biomarkers of inflammation;breath condensate;cysteinyl leukotrienes;nitrotyrosine;nitrate/nitrite;asthma control"@en . . "2005-07-18+02:00"^^ . "Nov\u00E1 diagnostick\u00E1 metoda pro stanoven\u00ED koncentrace ukazatel\u016F z\u00E1n\u011Btu a oxida\u010Dn\u00EDho stresu v kondenz\u00E1tu vydechovan\u00E9ho vzduchu jako m\u00EDry aktivity alergick\u00E9ho procesu u osob s astmatem a pylovou alergi\u00ED; u stanoven\u00ED leukotrien\u016F jde o sv\u011Btovou prioritu."@cs . "1"^^ . "asthma" . . "1"^^ . "breath condensate" . . "5"^^ . . "5"^^ . . "Biochemick\u00E9 markery z\u00E1n\u011Btu ve vydechovan\u00E9m vzduchu u d\u011Btsk\u00FDch astmatik\u016F jako nov\u00E1 metoda sledov\u00E1n\u00ED kontroly astmatu a prost\u0159edek pro optimalizaci farmakoterapie." . . "nitrate/nitrite" . "nitrotyrosine" . "cysteinyl leukotrienes" . . . "Prevalence pr\u016Fdu\u0161kov\u00E9ho astmatu ve sv\u011Bt\u011B stoup\u00E1 a manifestace onemocn\u011Bn\u00ED se posunuje st\u00E1le do mlad\u0161\u00EDch v\u011Bkov\u00FDch skupin. Pr\u016Fdu\u0161kov\u00E9 astma (PA) je chronick\u00FD alergick\u00FD z\u00E1n\u011Bt sliznice pr\u016Fdu\u0161ek (ZDC), kter\u00FD vyvol\u00E1v\u00E1 variabiln\u00ED d\u00FDchac\u00ED pot\u00ED\u017Ee. Invazivn\u00ED metody vy\u0161et\u0159en\u00ED ZDC (bronchoalveol\u00E1rn\u00ED lav\u00E1\u017E, biopsie pr\u016Fdu\u0161kov\u00E9 sliznice) jsou nevhodn\u00E9 pro opakovan\u00E9 vy\u0161et\u0159ov\u00E1n\u00ED aktivity ZDC v praxi a z etick\u00E9ho hlediska problematick\u00E9 u d\u011Bt\u00ED. Proto se v sou\u010Dasnosti hledaj\u00ED nov\u00E9 neinvazivn\u00ED metody. Projekt je zam\u011B\u0159en na stanoven\u00ED biochemick\u00FDch ukazatel\u016F a medi\u00E1tor\u016F z\u00E1n\u011Btu (BUMZ) (leukotrieny, dusitany/dusi\u010Dnany, Nitrotyrozin, peroxid vod\u00EDku) v kondenz\u00E1tu vydechovan\u00E9ho vzduchu (KVV). Hlavn\u00EDm c\u00EDlem projektu je validace metody vy\u0161et\u0159en\u00ED KVV, posouzen\u00ED jej\u00ED citlivosti a specifi\u010Dnosti p\u0159i monitorov\u00E1n\u00ED z\u00E1n\u011Btu u nemocn\u00FDch s astmatem a srovn\u00E1n\u00ED s pou\u017E\u00EDvan\u00FDmi metodami." . . "Biomarkers of airways inflammation in the breath condensate of children with asthma as a new noninvasive method of the asthma monitoring."@en . . . . . . . "http://www.isvav.cz/projectDetail.do?rowId=NL7024"^^ . "NL7024" . . "New diagnostic method for determination of inflammatory and oxidative stress markers in expired air condensates as a measure of activity of the alergic process in persons with asthma and pollinosis; determination of leukotrienes is a world priority."@en .