. "NL6709" . . . . "amoxicilin" . "diabetes foot infection" . . . "Pharmacokinetics of antibiotics in patients with infection complication of diabetic foot syndrome"@en . . "2004-07-12+02:00"^^ . "clindamycin" . . "Farmakokinetika antibiotik u nemocn\u00FDch s komplikacemi diabetu mellitu, p\u0159edev\u0161\u00EDm u syndromu diabetick\u00E9 nohy" . . "diabetes foot infection;pharmacokinetics;amoxicilin;clindamycin;ciprofloxacin"@en . "Diabetici s t\u011B\u017E\u0161\u00EDmi infek\u010Dn\u00EDmi komplikacemi u sy. diabetick\u00E9 nohy, jsou obvykle dlouhodob\u011B l\u00E9\u010Deni parenter\u00E1ln\u00EDmi antibiotiky, p\u0159i dol\u00E9\u010Dov\u00E1n\u00ED jejich peror\u00E1ln\u00EDmi formami. M\u00EDra a rychlost absorpce t\u011Bchto l\u00E9\u010Div v\u0161ak u diabetik\u016F nen\u00ED dostate\u010Dn\u011B dokumentov\u00E1na.Chceme analyzovat koncentrace amoxicilinu, klindamycinu a ciprofloxacinu v s\u00E9ru a ev. m\u011Bkk\u00FDch tk\u00E1n\u00EDch metodou HPLC a porovnat kinetick\u00E9 parametry u t\u00E9ho\u017E nemocn\u00E9ho po jejich peror\u00E1ln\u00EDm i inf\u00FAzn\u00EDm pod\u00E1n\u00ED ve vztahu k MIC mikrob\u016F vyvol\u00E1vaj\u00EDc\u00EDch infekci." . . . "0"^^ . "Long term parenteral antibiotic treatment is used in diabetic patients with severe foot infection. Then are switched to orally administered drugs. Extent and rate of absorption of these drugs are not well documented in diabetics. Serum and event. soft tissue concentration of amoxicillin, clindamycin, and ciprofloxacin (using HPLC method) will be analysed in the same individual after iv infusion and oral administration of drugs in comparison with healing rate and microbial MIC."@en . . . "1"^^ . "pharmacokinetics" . "0"^^ . "1"^^ . "1"^^ . "V\u00FDsledky prokazuj\u00ED mo\u017Enost zkr\u00E1cen\u00ED hospitalizace po p\u0159echodu na peror\u00E1ln\u00ED formu l\u00E9\u010Dby, kter\u00E1 je levn\u011Bj\u0161\u00ED a m\u00E9n\u011B omezuje b\u011B\u017En\u00FD \u017Eivotn\u00ED re\u017Eim nemocn\u00FDch."@cs . "http://www.isvav.cz/projectDetail.do?rowId=NL6709"^^ . . . . .