"NL6431" . . . . "Pravd\u011Bpodobnostn\u00ED modely rozpou\u0161t\u011Bn\u00ED, doby setrv\u00E1n\u00ED a interakc\u00ED l\u00E9\u010Divo-receptor ve farmakokinetik\u00E1ch" . "pharmacokinetics" . "pharmacokinetics;drug-receptor;dissolution;residence time;nonlinear analysis"@en . "Stochastic models of dissolution, residence time and drug-receptor interaction in pharmacokinetics"@en . "Byl navr\u017Een model \u010Dasov\u00E9 dynamiky rozpou\u0161t\u011Bn\u00ED frakce, nalezen postup odhad\u016F rychlosti rozpou\u0161t\u011Bn\u00ED a p\u0159edv\u00EDd\u00E1n\u00ED n\u00E1hodn\u00FDch fluktuac\u00ED rychlosti rozpou\u0161t\u011Bn\u00ED d\u016Fle\u017Eit\u00FDch pro interakce l\u00E9\u010Divo-receptor."@cs . . . "1"^^ . . "drug-receptor" . "residence time" . "3"^^ . . "0"^^ . "3"^^ . . "Navr\u017Een\u00ED statistick\u00FDch metod pro anal\u00FDzu experiment\u016F s rozpou\u0161t\u011Bn\u00EDm nehomogenn\u00EDch substanc\u00ED. Nalezen\u00ED optim\u00E1ln\u00ED \u010Dasov\u00E9 struktury pod\u00E1v\u00E1n\u00ED l\u00E9\u010Div v stochastick\u00E9m v\u00EDcekompartmentov\u00E9m syst\u00E9mu. Studium \u010Dasov\u00E9ho pr\u016Fb\u011Bhu p\u016Fsoben\u00ED l\u00E9\u010Diva pro p\u0159\u00EDpad, \u017Ee interakce substance-receptor je statisticky variabiln\u00ED." . "2004-07-12+02:00"^^ . "0"^^ . . . . . "dissolution" . . . "http://www.isvav.cz/projectDetail.do?rowId=NL6431"^^ . . . "To propose statistical methods for inference on dissolution data from non homogenous drugs. To devise a method for optimum drug administration in stochastic multicompartment system. To deduce time-profile of drug action in the case, in which the drug-receptor interaction is statistically fluctuating."@en .