"Functional tests in the heterologous systems of glutamate metabotropic receptors modified using classical mutagenesis techniques will reveal the portions of the receptors involved in signal transduction determination Understanding the molecular mechanism of signal transduction of glutamate matabotropic receptors is essential in the developement of new drugs."@en . "Funk\u010Dn\u00EDm testov\u00E1n\u00EDm c\u00EDlen\u011B mutovan\u00FDch metabotropn\u00EDch glutam\u00E1tov\u00FDch receptor\u016F a G-protein\u016F chceme odhalit struktur\u00E1ln\u00ED \u00FAseky na obou partnerech kter\u00E9 umo\u017E\u0148uj\u00ED jejich komunikaci. Nov\u00E9 poznatky o v\u00FDb\u011Bru sign\u00E1ln\u00EDch kask\u00E1d t\u011Bchto receptor\u016F jsou d\u016Fle\u017Eit\u00E9 pro na\u0161e pochopen\u00ED mechanismu jejich aktivace a prakticky aplikovateln\u00E9 hlavn\u011B p\u0159i v\u00FDvoji nov\u00FDch l\u00E9k\u016F." . "http://www.isvav.cz/projectDetail.do?rowId=NL6114"^^ . "Excitatory" . . . "Byly zavedeny techniky studia molekul\u00E1rn\u00EDch mechanism\u016F metabotropn\u00EDch receptor\u016F a autor p\u0159enesl sv\u00E9 zku\u0161enosti ze zahrani\u010D\u00ED na pracovi\u0161t\u011B v \u010CR."@cs . "Structural determinants of transduction of the metabotropic glutamate receptors"@en . . . "GTP binding Proteins" . "G-Proteins" . . "Glutamane;Receptors;GTP binding Proteins;G-Proteins;Synapsis;Excitatory;Signal Transduction;Intracellular"@en . "2003-07-31+02:00"^^ . "Signal Transduction" . . . "0"^^ . "Glutamane" . . . "Synapsis" . "1"^^ . "0"^^ . "Struktur\u00E1ln\u00ED determinanty p\u0159enosu sign\u00E1l\u016F u metabotropn\u00EDch glutam\u00E1tov\u00FDch receptor\u016F" . "1"^^ . "NL6114" . . "1"^^ . . . . . . . . "Receptors" .