. "NL4668" . . . "Studium \u00FA\u010Dink\u016F r\u016Fzn\u00FDch anxiolytik na my\u0161\u00EDch bude roz\u0161\u00ED\u0159eno o testov\u00E1n\u00ED neuroaktivn\u00EDch steroid\u016F. Struktura steroid\u016F bude modifikov\u00E1na tak, aby byla zv\u00FD\u0161ena jejich rozpustnost ve vod\u011B a jejich stabilita v\u016F\u010Di metabolick\u00E9 degradaci. Typy modifikac\u00ED budou odvozov\u00E1ny ze znalost\u00ED strukturn\u00EDch rys\u016F esenci\u00E1ln\u00EDch pro vazbu stereoid\u016F na GABA receptor." . . "Water-soluble derivatives of neuroactive steroids will be synthesized and their anxiolytic,sedative and other neuropsychotropic activities will be tested in animalis. The structure of the steroids will be modified in order to increase their solubility and their stability towards metabolic degradation. The zypes of these structural modifications will be chosen with knowledge of structural features essential for the binding to a GABAa receptor complex."@en . . . . "The Synthesis of Water-soluble Derivative of Neuroactive Steroids and Evaluation of Their Neuropsychotropic Activity"@en . . . . . "12"^^ . "P\u0159\u00EDprava vodorozpustn\u00FDch deriv\u00E1t\u016F neuroaktivn\u00EDch steroid\u016F" . "1"^^ . "12"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NL4668"^^ . . "0"^^ . "V\u00FDstupem projektu je jedna farmakologicky \u00FA\u010Dinn\u00E1 l\u00E1tka s anxiolytick\u00FDmi vlastnostmi. Publikace: Soll.Czech.Chem. Com, Tetrahedion"@cs . . . "0"^^ .