. . "hsp90" . "Byl p\u0159ipraven rekombinantn\u00ED protein hsp90 C.albicans a p\u0159\u00EDslu\u0161n\u00E1 DNA vakc\u00EDna,je\u017E byly otestov\u00E1ny na modelech syst\u00E9mov\u00E9 a vagin\u00E1ln\u00ED kandid\u00F3zy my\u0161\u00ED.Efekty vakcinac\u00ED byly hodnoceny experim.navozenou infekc\u00ED a stanov. parametr\u016F humor\u00E1ln\u00ED a bun\u011B\u010Dn\u00E9 imunity."@cs . . "Th1 response" . "DNA vaccine;hsp90;recombinant protein;Th1 response;humoral immunity;vaginal candidiasis;disseminated candidiasis;mouse model"@en . "disseminated candidiasis" . . "humoral immunity" . . . . "vaginal candidiasis" . "Comparison of a Recombinant hsp90 Protein Vaccine and DNA Vaccine Protectivity in Mouse Vaginal and Systemic Candidiasis Model"@en . "Protein hsp90 Candida albicans pat\u0159\u00ED mezi imunodominantn\u00ED potenci\u00E1ln\u011B protektivn\u00ED antigeny schopn\u00E9 indukovat specifick\u00E9 T lymfocyty a imunoglobul\u00EDny je\u017E mohou p\u0159isp\u011Bt ke kontrole muk\u00F3zn\u00ED ale i syst\u00E9mov\u00E9 kandid\u00F3zy. Vznik autoimunity po imunizaci hsp90 nebyl jednozna\u010Dn\u011B potvrzen a sp\u00ED\u0161e se ukazuje mo\u017En\u00FD protektivn\u00ED efekt p\u0159i kontrole autoimunitn\u00EDch proces\u016F. Hsp90 vakcina\u010Dn\u00ED strategie je tedy slibnou alternativou k sou\u010Dasn\u00E9 terapii antifung\u00E1ln\u00EDmi l\u00E1tkami. Nalezen\u00ED optim\u00E1ln\u00ED formy hsp90 vakcinace zaji\u0161\u0165uj\u00EDc\u00ED ochranu vakcinovan\u00FDch zv\u00ED\u0159at b\u011Bhem modelov\u00E9 kandid\u00F3zy je prvn\u00EDm krokem p\u0159i v\u00FDvoji hsp90 vakc\u00EDny pro prevenci a terapii muk\u00F3zn\u00ED \u010Di syst\u00E9mov\u00E9 kandid\u00F3zy u \u010Dlov\u011Bka." . . . . "Srovn\u00E1n\u00ED protektivn\u00EDho efektu hsp90 rekombinantn\u00ED proteinov\u00E9 a DNA vakcinace my\u0161\u00ED u modelov\u00E9 syst\u00E9mov\u00E9 a vagin\u00E1ln\u00ED kandid\u00F3zy." . "2006-06-23+02:00"^^ . "recombinant protein" . "http://www.isvav.cz/projectDetail.do?rowId=NI7538"^^ . "0"^^ . "The recombinant hsp90 C.albicans protein and respective DNA vaccine were prepared and tested in mice models of systemic and vaginal candidiasis.Effects of vaccinations approaches were tested in challenge experiments.Humoral and cell immune paramenters."@en . . . . . "NI7538" . . . "1"^^ . "Candida albicans hsp90 protein is considered as an immunodominant potentially protective antigen suitable to induce specific T cells and specific antibodies protective against mucosal and disseminated candidiasis. Induction of autoimmunity after immunisation with hsp90 was not yet described unambiguously. Conversely they are some evidences that the anti-hsp response is protective. Consequently hsp90 vaccination is promising alternative to antifungal drug therapy."@en . . . . "3"^^ . . "0"^^ . "3"^^ . "DNA vaccine" . .