. . "Autoimmunity" . "2005-07-18+02:00"^^ . . "Anal\u00FDza peptid\u016F prezentovan\u00FDch HLA-B27 molekulami u zdrav\u00FDch a nemocn\u00FDch jedinc\u016F s autoimunitn\u00EDmi chorobami: v\u00FDvoj diagnostick\u00E9 metody." . . . . "P\u0159edb\u011B\u017En\u00E9 v\u00FDsledky n\u00E1m umo\u017Enily pool sekvenov\u00E1n\u00ED peptid\u016F z\u00EDskan\u00FDch z kapsy HLA-B27 molekul z 400 ml krve. Tento postup bude propracov\u00E1n tak, aby umo\u017Enil stavoven\u00ED peptidick\u00E9ho profilu (PF) z HLA molekul z 200 ml krve. Metodologie umo\u017E\u0148uj\u00EDc\u00ED vy\u0161et\u0159en\u00ED PF HLA molekul z mal\u00E9ho (200 ml) mno\u017Estv\u00ED krve bude pou\u017Eita pro srovn\u00E1n\u00ED PF u nemocn\u00FDch s ankylozuj\u00EDc\u00ED spondylartritidou a zdrav\u00FDch jedinc\u016F. V\u00FDsledek p\u0159isp\u011Bje k pochopen\u00ED v\u00FDznamu HLA antigen\u016F pro vznik autoimunity. Budou z\u00EDsk\u00E1ny \u00FAdaje o PF HLA molekul od zdrav\u00FDch a nemocn\u00FDch jedinc\u016F. Budou vypracov\u00E1ny statistick\u00E9 metody umo\u017E\u0148uj\u00EDc\u00ED kritick\u00E9 a detailn\u00ED posouzen\u00ED rozd\u00EDl\u016F v PF zdrav\u00FDch a nemocn\u00FDch jedinc\u016F." . . . "NI7327" . "HLA molecules" . . . "V\u00FDsledkem \u0159e\u0161en\u00ED projektu je z\u00EDsk\u00E1n\u00ED informac\u00ED o peptidech v\u00E1zan\u00FDch v HLA antigenu B27, d\u00E1le metodologick\u00E1 pr\u00E1ce t\u00FDkaj\u00EDc\u00ED se modifikace HPLC. Poznatky roz\u0161i\u0159uj\u00ED na\u0161e v\u011Bdomosti o patogenezi autoimunitn\u00EDch chorob."@cs . "http://www.isvav.cz/projectDetail.do?rowId=NI7327"^^ . "8"^^ . . . . . "8"^^ . "Autoimmunity;HLA molecules;Peptides;Spomdylarthrozis"@en . "The project lead to new knowledge about peptides that bind into the groove of MHC antigen HLB-27. Also an article about modification of HPLC was published. Information obtained give us more knowledge about pathogenesis of autoimmune diseases."@en . . . "1"^^ . "Peptides" . . . . "1"^^ . "Our pereliminary results show the possibility of pool sequencing of peptides isolated from the grooves of HLA-B27 molecules from 400 ml blood. This technology will be further elaborated to obtain peptide profiles (PP) from HLA molekules from 200 ml blood Methodology, which enables to establish PP from small numbers of cells, will be applied for comparison of PP from patients with ankylosing spondylarthrosis and healthy individuals. The reults will contribute to understand the role of HLA in autoimmunity. Numerous data will be obtained on PP of HLA molecules from diseased and healthy individuals. Statistical methods will be elaborated to enable detailed and critical evaluation of differences in PP from healthy and diseased individuals."@en . "0"^^ . "Analysis of Peptides Presented by HLA-B27 Molecules on Healthy Individuals and on Individuals with Autoimmune Disease: Development of Diagnostic Method"@en . .