"Molekul\u00E1rn\u011B genetick\u00E1 studie modifikovan\u00FDch TFO(triplex forming oligonucleotides):nov\u00FD p\u0159\u00EDstup v genov\u00E9 terapii latentn\u00ED HIV infekce." . "0"^^ . "2003-07-31+02:00"^^ . "NI6180" . . . . "TFO" . "0"^^ . "2"^^ . . "oligonucleotides" . "2"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NI6180"^^ . "1"^^ . . . . "triplex" . "DNA" . "Project is focused on study of gene tergeted triplex forming oligonucleotides (TFO) and their conjugates with red-shifted wavelenghts photoactivable DNA-destructing molecules in anti-HIV gene therapy. The project is based on triplex terget sites in HIV provirus search,TFOs designing and evalution of binding and cleavage properties of TFOs in vitro and in cell culture by in project described methods."@en . "HIV" . . "mocule" . . . . "photoactivable" . "I kdy\u017E v\u0161echny c\u00EDle projektu nebyly v term\u00EDnu spln\u011Bny, nelze v \u017E\u00E1dn\u00E9m p\u0159\u00EDpad\u011B hodnotit projekt jako ne\u00FAsp\u011B\u0161n\u00FD a vynalo\u017Een\u00E9 prost\u0159edky za zmarn\u011Bn\u00E9. Journal of Chromatography B - bez dolo\u017Een\u00E9 dedikace."@cs . "Projekt je zam\u011B\u0159en na studium genov\u011B c\u00EDlen\u00FDch triplax tvo\u0159\u00EDc\u00EDch oligonukleotid\u016F a jejich konjug\u00E1t\u016F s DNA-destruj\u00EDc\u00EDmi molekulami aktivovateln\u00FDmi bl\u00EDzce infra\u010Derven\u00FDm z\u00E1\u0159en\u00EDm v genov\u00E9 terapii HIV infekce. Projekt je zalo\u017Een na vyhled\u00E1v\u00E1n\u00ED vhodn\u00FDch sekvenc\u00ED pro TFO v genomu proviru HIV,n\u00E1vrh TFO a studium vazebn\u00FDch a \u0161t\u011Bp\u00EDc\u00EDch schopnosti TFO in vitro a v bun\u011B\u010Dn\u00E9 kultu\u0159e metodami bl\u00ED\u017Ee popsan\u00FDmi v tomto projektu." . "Molecular genetic study of modified TFO(triplex forming oligonucleotides):new approach in latent HIV gene therapy."@en . . . "HIV;triplex;oligonucleotides;TFO;photoactivable;mocule;DNA;cleavage"@en . . . .