"FISH" . . "genetic marker" . "1"^^ . "1"^^ . . "3"^^ . "3"^^ . "tumour-supressor gene" . "cervical cancer;ovarian cancer;FISH;CGH;image analysis;genetic marker;tumour-supressor gene;oncocytogenetics"@en . . "V 60 vzorc\u00EDch ovari\u00E1ln\u00EDho a ve 20 cervik\u00E1ln\u00EDho karcinomu byly zji\u0161t\u011Bny statisticky v\u00FDznamn\u00E9 korelace mezi stadiem, histologi\u00ED, gradingem, response rate, genet.zm\u011Bnami, p53, MIB 1, CA 125 jako v\u00FDchodisko pro predikci progn\u00F3zy onemocn\u011Bn\u00ED."@cs . "0"^^ . "NH7659" . . "Predictive value of molecular biological parameters in malignant gynaecological tumours"@en . "image analysis" . . . "In 60 samples of ovarian and 20 or cervical cancer statstically significant correlations were established between stage,histology, grading, RR, chromosomal rearrangements, p53, MIB 1, CA 125 serving as a basis for prediction of disease prognosis."@en . "The samples of tumour tissue (cervical cancer and ovarian cancer) will be processed with the aim of cytogenetic examination and establishment of biomolecular parameters, which have predictive value for the next course of the disease. In order to establish numerical and structural aberrations in the karyotype of tumour cells FISH method (fluorescent in situ hybridization),CGH (comparative genome hybridisation) and cytogenetic analysis of non-cultivated and cultivated will be applied. A part of the sample will be examined immunohistochemically. Obtained results will be statistically evaluated in correlation to other available characteristics and clinical course of disease using univariate and multivariate regression analysis."@en . . . . . . "CGH" . . "2006-06-23+02:00"^^ . . . "cervical cancer" . "ovarian cancer" . "http://www.isvav.cz/projectDetail.do?rowId=NH7659"^^ . . . . . "Vzorky n\u00E1dorov\u00E9 tk\u00E1n\u011B /karcinom cervixu a karcinom ovaria/ budou zpracov\u00E1ny za \u00FA\u010Delem cytogenetick\u00E9ho vy\u0161et\u0159en\u00ED a stanoven\u00ED molekul\u00E1rn\u011B biologick\u00FDch parametr\u016F, kter\u00E9 maj\u00ED prediktivn\u00ED v\u00FDznam pro dal\u0161\u00ED v\u00FDvoj onemocn\u011Bn\u00ED. Ke stanoven\u00ED numerick\u00FDch a strukturn\u00EDch aberac\u00ED v karyotypu n\u00E1dorov\u00FDch bun\u011Bk bude pou\u017Eita metodika FISH /fluorescen\u010Dn\u00ED in situ hybridizace/, CGH /komparativn\u00ED genomov\u00E1 hybridizace/ a cytogenetick\u00E1 anal\u00FDza nekultivovan\u00FDch a kultivovan\u00FDch bun\u011Bk. \u010C\u00E1st vzorku bude vy\u0161et\u0159ena imunohistochemicky.Z\u00EDskan\u00E9 v\u00FDsledky budou statisticky vyhodnoceny v korelaci s dal\u0161\u00EDmi dostupn\u00FDmi charakteristikami a klinick\u00FDm pr\u016Fb\u011Bhem onemocn\u011Bn\u00ED metodami jednorozm\u011Brn\u00E9 i mnohorozm\u011Brn\u00E9 anal\u00FDzy dat." . "Prediktivn\u00ED v\u00FDznam molekul\u00E1rn\u011B biologick\u00FDch parametr\u016F u gynekologick\u00FDch zhoubn\u00FDch n\u00E1dor\u016F" . .