"Vy\u0161et\u0159en\u00ED mutace 657de15 v NBS1 genu v souboru pacient\u016F s malignitami ke zdokonalen\u00ED diagnostiky, l\u00E9\u010Dby a prevence autosom\u00E1ln\u011B recesivn\u011B d\u011Bdi\u010Dn\u00E9ho syndromu chromosom\u00E1ln\u00ED instability a hyperradiosensitivy NBS predisponuj\u00EDc\u00ED k malignit\u00E1m." . "0"^^ . . . "V\u00FDsledkem je diagnostick\u00E1 metoda s v\u00FDznamn\u00FDm klinick\u00FDm dopadem."@cs . "2004-07-12+02:00"^^ . . . "DNA analysis" . . "Detekce Nijmegen breakage syndromu mezi pacienty s malignitami p\u0159\u00EDmou DNA anal\u00FDzou" . . . . . "Nijmegen breakage syndrome" . . "NBS1 gene" . . "6"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=NH6439"^^ . "6"^^ . "0"^^ . "Nijmegen breakage syndrome;DNA analysis;NBS1 gene;nibrin;657de15"@en . "Detection of Nijmegen Breakakge Syndrom (NBS) by DNA analysis among patients with malignancies"@en . "nibrin" . "1"^^ . "Detection of 657de15 mutation of NBS1 gene in patients with malignancy for improvement of diagnosis,treatment and prevention of autosomal recessive inherited DNA repair disorder and hyperradiosensitivity NBS which predisposes to malignancies. Patients with malignancy,who are carrier of NBS1 gene mutation,must be treated with low doses of cytostatica and protect trom radiotherapy."@en . . "NH6439" . . . .