"0"^^ . "NF7594" . "2006-06-23+02:00"^^ . "apoptosis" . . "neural grafting" . . "The therapy of Huntington's disease is very limited at the present time. Neural grafting is now the only therapeutic approach which provides a reduction of symptoms in most of the patients, but only temporarily. It seems that stimulation of proliferative activity within the subependymal layer (SEL] of the lateral brain ventricles may provide another alternative. The SEL is a source of progenitor cells even in adulthood. Our aim is to describe the SEL cell's reaction in the experimental animals. We would like to characterize the basic types of cells within the SEL and the changes in their number. These changes are supposed to be caused by proliferation and degeneration (mostly by apoptosis), which is induced by the neurodegenerative process within the striatum (neurotoxic lesion) and by the following grafting of the fetal neural tissue."@en . . "Terapie Huntingtonovy chorey je zat\u00EDm jen velmi omezen\u00E1. Neur\u00E1ln\u00ED transplantace je nyn\u00ED jedin\u00FDm l\u00E9\u010Debn\u00FDm z\u00E1krokem, kter\u00FDm se u v\u011Bt\u0161iny pacient\u016F dos\u00E1hne zm\u00EDrn\u011Bn\u00ED projev\u016F onemocn\u011Bn\u00ED, av\u0161ak \u010Dasov\u011B omezen\u00E9ho. Dal\u0161\u00ED mo\u017Enost\u00ED by, jak se zd\u00E1, mohla b\u00FDt stimulace prolifera\u010Dn\u00ED aktivity v subependym\u00E1ln\u00ED vrstv\u011B (SEV) later\u00E1ln\u00EDch mozkov\u00FDch komor. SEV je zdrojem progenitorov\u00FDch bun\u011Bk i v dosp\u011Blosti. Na\u0161\u00EDm z\u00E1m\u011Brem je popsat reakci bun\u011Bk v SEV u experiment\u00E1ln\u00EDch zv\u00ED\u0159at. Chceme charakterizovat z\u00E1kladn\u00ED typy bun\u011Bk v SVZ a zm\u011Bny v jejich po\u010Dtu. P\u0159edpokl\u00E1d\u00E1 se, \u017Ee k t\u011Bmto zm\u011Bn\u00E1m doch\u00E1z\u00ED v d\u016Fsledku proliferace a degenerace (p\u0159edev\u0161\u00EDm apopt\u00F3zou), navozen\u00E9 neurodegenerativn\u00EDm procesem ve striatu (neurotoxick\u00E1 l\u00E9ze) a n\u00E1slednou transplantac\u00ED fet\u00E1ln\u00ED nervov\u00E9 tk\u00E1n\u011B." . . . "subependymal layer" . "morphology" . "The experimental model of Huntington's disease: The reaction of the subependymal layer of lateral ventricles to neurodegenerative process within the striatum, and to the fetal neural graft."@en . . . "http://www.isvav.cz/projectDetail.do?rowId=NF7594"^^ . . "prioritn\u00ED n\u00E1lezy t\u00FDkaj\u00EDc\u00ED se aktivace neurogen.niche neurodegenerativ.procesem ve striatu a poznatky o vztahu neur\u00E1l.\u0161t\u011Bpu a tk\u00E1n\u011B p\u0159\u00EDjemce-ovlivn\u011Bn\u00ED jejich integrace progras\u00ED patolog.zm\u011Bn ve striatu,v\u010D.mo\u017En\u00E9 aplikace t\u011Bchto n\u00E1lez\u016F u pacient\u016F s HD."@cs . . "Huntington's disease" . . "Huntington's disease;neural grafting;neurotoxic lesion;subependymal layer;apoptosis;morphology;immunohistochemistry;quantification"@en . . . "5"^^ . . "immunohistochemistry" . "Experiment\u00E1ln\u00ED model Huntingtonovy chorey: Reakce subependymov\u00E9 vrstvy postrann\u00EDch mozkov\u00FDch komor na neurodegenerativn\u00ED proces ve striatu a na fet\u00E1ln\u00ED neur\u00E1ln\u00ED transplant\u00E1t." . "5"^^ . . "Primary results concerning the activation of neurogenic niche in respnse to neurodeg.of the striatum,and neural graft-host retionship,esp.that their integration is influenced by progression of striatal pathology-the applicat. is possible in HD patients."@en . "neurotoxic lesion" . . . . . . "1"^^ . . "1"^^ .