"0"^^ . "ontogenesis" . "nootropic drugs" . . "0"^^ . . "psychomotor development" . . . . . "excitatory aminoacids" . "Jak\u00E9 jsou dlouhodob\u00E9 d\u016Fsledky po\u0161kozen\u00ED mozku a neuroprotektivn\u00ED l\u00E9\u010Dby na dal\u0161\u00ED v\u00FDvoj motorick\u00FDch a kognitivn\u00EDch funkc\u00ED nezral\u00E9ho jedince?" . "2004-07-12+02:00"^^ . . . "What are long-term consequences of brain damage and neuroprotective therapy on psychomotor development of immature individuals?"@en . "ontogenesis;neuronal damage;excitatory aminoacids;psychomotor development;status epilepticus;nootropic drugs;neuroprotection;apoptosis"@en . "Status epilepticus has detrimental effects on brain. Its consequences in developing brain differ from those in mature brain; in addition to neuronal death subsequent development may be compromised not only by status but also by drugs used for therapy. Long-term functional and morphological consequences of experimental status epilepticus will be studied in two age groups of immature laboratory rats. Relationship between extension and character of brain damage and period after SE will be also examined. To prevent consequences of status epilepticus antagonists of excitatory aminoacids, nootropics and apoptosis blockers will be used. The effects of these drugs on normal development of intact animals will be examined. Data from these experiments allow to decide if therapeutic and neuroprotective actions overweight possible negative influence of aggressive therapy on development."@en . "NF6474" . . "neuronal damage" . . "neuroprotection" . "Nov\u00E9 poznatky o \u00FA\u010Dinc\u00EDch antiepileptik zvl\u00E1\u0161t\u011B v d\u011Btsk\u00E9m v\u011Bku."@cs . . . . "7"^^ . . . "7"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NF6474"^^ . . "1"^^ . "Status epilepticus (SE) po\u0161kozuje mozek. N\u00E1sledky u nezral\u00FDch a dosp\u011Bl\u00FDch jedinc\u016F jsou rozd\u00EDln\u00E9: k z\u00E1niku neuron\u016F se v nezral\u00E9m mozku p\u0159id\u00E1v\u00E1 je\u0161t\u011B ovlivn\u011Bn\u00ED v\u00FDvoje statem, ale i pou\u017Eitou terapi\u00ED. D\u016Fle\u017Eit\u00FD je i stupe\u0148 v\u00FDvoje, na kter\u00E9m status prob\u011Bhne. Budeme studovat dlouhodob\u00E9 funk\u010Dn\u00ED a morfologick\u00E9 zm\u011Bny po lithium-pilokarpinov\u00E9m statu u dvou v\u011Bkov\u00FDch skupin ml\u00E1\u010Fat laboratorn\u00EDch potkan\u016F. Pozornost bude v\u011Bnov\u00E1na i rozvoji mozkov\u00E9 l\u00E9ze v z\u00E1vislosti na dob\u011B p\u0159e\u017Eit\u00ED po statu. K prevenci n\u00E1sledk\u016F pou\u017Eijeme l\u00E1tky, u kter\u00FDch byl nalezen pozitivn\u00ED efekt na mozkov\u00E9 po\u0161kozen\u00ED u dosp\u011Bl\u00FDch jedinc\u016F, tj. antagonisty excita\u010Dn\u00EDch aminokyselin (NMDA i AMPA receptor\u016F), nootropika a d\u00E1le blok\u00E1tory apopt\u00F3zy. paraleln\u011B budeme sledovat vliv testovan\u00FDch l\u00E1tek na morfologick\u00FD a funk\u010Dn\u00ED v\u00FDvoj intaktn\u00EDch jedinc\u016F. V\u00FDsledky umo\u017En\u00ED posoudit, zda je terapeutick\u00FD a neuroprotektivn\u00ED p\u0159\u00EDnos v\u00FDznamn\u011Bj\u0161\u00ED ne\u017E mo\u017En\u00FD negativn\u00ED dopad agresivn\u00ED terapie na dal\u0161\u00ED v\u00FDvoj mozku." . "status epilepticus" . . .