. "GenWT1 je hyperexprimov\u00E1n v oblastech \u010D\u00E1sti d\u011Btsk\u00FDch pacient\u016F s hematolog.malignitami,tato hyperexprese v\u0161ak nen\u00ED jednozna\u010Dn\u00FDm markerem n\u00E1dorov\u00E9ho procesu.Vyu\u017Eit\u00ED v detekci rezidu\u00E1ln\u00ED nemoci je mo\u017En\u00E9 z\u0159ejm\u011B u pacient\u016F s akut.myel.leuk\u00E9mi\u00ED."@cs . "Significance of WT1 gene expression for prognosis and residual disease monitoring in childhood acute leukeamias."@en . . . "WT1" . "minimal residual disease" . "NE7439" . . "RQ-PCR" . "Proposed study will test prospectively the prognostic significance of WT1 expression at presentation and during therapy of paediatric acute myeloid leukemia. Quantitaion of WT1 transcript levels by real-time quantitative reverse-transcription PCR will be compared to flow cytometry detection of minimal residual disease."@en . "1"^^ . . . "0"^^ . "http://www.isvav.cz/projectDetail.do?rowId=NE7439"^^ . "2"^^ . "2"^^ . . "0"^^ . "WT1;childhood AML;minimal residual disease;RQ-PCR;flow cytometry;stem cell transplantation"@en . "2006-06-23+02:00"^^ . . "WT1gene is hyperexpressed in blasts of a proportion of childhood patients with haematological malignancies but it si not an unequivocal marker of malignant process.It can be used form residual disease detection in patients with acute myeloid leukaemia."@en . . "Navrhovan\u00E1 studie bude prospektivn\u011B testovat prognostick\u00FD v\u00FDznam exprese WT1 p\u0159i diagn\u00F3ze a v pr\u016Fb\u011Bhu l\u00E9\u010Dby akutn\u00ED myeloidn\u00ED leukemie. Porovn\u00E1me hladiny exprese WT1 kvantifikovan\u00E9 pomoc\u00ED %22real-time\u016F reversn\u011B transkript\u00E1sov\u00E9 PCR s detekc\u00ED residu\u00E1ln\u00ED nemoci pomic\u00ED pr\u016Ftokov\u00E9 cytometrie." . . "childhood AML" . "flow cytometry" . . . . . . . . . . "V\u00FDznam genu WT1 pro prognosu a sledov\u00E1n\u00ED residu\u00E1ln\u00ED nemoci u d\u011Btsk\u00FDch leukemi\u00ED" . . .