"Treatment results of Czech children with ALL improved by partic.in the int. ALL IC-BFM 2002study. PCR detection of IgH+TCR rearrangements is more sens.assessment of min.residual disease than flow cytometry and mofphological eval.of early treatm.response"@en . "0"^^ . . . "treatment" . "The aim is the improvement of diagnosis and treatment results in Czech children with ALL by collaboration in the large international randomized study dividing patients into the risk groups according to the genotype and early treatment response. Cytometric assessment of minimal residual disease confirms the assigmnemt to the risk groups by the warly treatment response. Simultaneous PCR detection of the IgH and TCR rearrangements confirms assignment to the standard risk group."@en . . "acute lymphoblastic" . "children" . . . . . "http://www.isvav.cz/projectDetail.do?rowId=NE6929"^^ . . . . . . "NE6929" . "\u010Casn\u00E1 odpov\u011B\u010F na l\u00E9\u010Dbu jako nejv\u00FDznamn\u011Bj\u0161\u00ED prognostick\u00FD faktor d\u011Btsk\u00E9 akutn\u00ED lymfoblastick\u00E9 leukemie v nov\u00E9 mezin\u00E1rodn\u00ED l\u00E9\u010Debn\u00E9 studii" . "Early treatment response as the most important prognostic factor in childhood acute lymphoblastic leukemia in the new international treatment protocol"@en . . . . . "C\u00EDlem studie je zlep\u0161it diagnostiku a v\u00FDsledky l\u00E9\u010Dby d\u011Bt\u00ED s akutn\u00ED lymfoblastickou leukemi\u00ED v \u010Cesk\u00E9 republice zapojen\u00EDm do mezin\u00E1rodn\u00ED randomizovan\u00E9 studie, rozd\u011Bluj\u00EDc\u00ED pacienty do rizikov\u00FDch skupin podle genotypu leukemie a \u010Dasn\u00E9 odpov\u011Bdi na l\u00E9\u010Dbu. Stanoven\u00EDm minim\u00E1ln\u00ED residu\u00E1ln\u00ED nemoci detekc\u00ED aberantn\u00EDho imunofenotypu ov\u011B\u0159it spr\u00E1vnost rozd\u011Blen\u00ED pacient\u016F do rizikov\u00FDch skupin podle \u010Dasn\u00E9 odpov\u011Bdi na l\u00E9\u010Dbu a PCR metodou detekce p\u0159edstaveb Ig a TCR charakterizovat skupinu standardn\u00EDho rizika." . "5"^^ . "minimal residula disease" . "5"^^ . . . . . "acute lymphoblastic;treatment;children;minimal residula disease;prognosis"@en . "2006-06-23+02:00"^^ . "1"^^ . "V\u00FDsledky l\u00E9\u010Dby d\u011Bt\u00ED s ALL se v \u010CR zlep\u0161ily \u00FA\u010Dast\u00ED v mez.studii ALL IC-BFM 2002. PCR detekce p\u0159estaveb Ig a TCR je ve srovn\u00E1n\u00ED s pr\u016Ftokovou cytometri\u00ED a mrfologick\u00FDm hodnocen\u00EDm \u010Dasn\u00E9 odpov\u011Bdi na l\u00E9\u010Dbu citliv\u011Bj\u0161\u00ED metodou stanoven\u00ED minim\u00E1ln\u00ED rezidu\u00E1l.nemoci"@cs . "1"^^ .