"2004-07-12+02:00"^^ . . . "DAZ a" . "0"^^ . "Projekt je rozs\u00E1hl\u00FD soubor \u00FAkol\u016F, studi\u00ED, jeho\u017E v\u00FDstupem je v\u00EDce nov\u00FDch diagnostick\u00FDch a l\u00E9\u010Debn\u00FDch metod. Nen\u00ED v\u0161ak spln\u011Bna podm\u00EDnka publikov\u00E1n\u00ED v \u010Dasopise s IF a v\u00FDlu\u010Dn\u00E1 dedikace IGA pouze k dan\u00E9mu projektu."@cs . " b" . . "0"^^ . . . "FISH/PRINS" . "1"^^ . . . . . . "7"^^ . . "Zdokonalen\u00ED metod asistovan\u00E9 reprodukce laserovou mikromanipulac\u00ED ke zv\u00FD\u0161en\u00ED rychlosti, biologick\u00E9 bezpe\u010Dnosti a zv\u00FD\u0161en\u00E9ho \u00FAsp\u011Bchu IVF pro asistovan\u00FD hatching, biopsii I.pol\u00E1rn\u00EDho t\u011Bl\u00EDska, imobilizaci spermi\u00ED bez biologicky rizikov\u00E9ho PVP. Molekul\u00E1rn\u011B cytogenetick\u00E1/genetick\u00E1 diagnostika aneuploidi\u00ED a mutac\u00ED CFTR genu v I.pol\u00E1rn\u00EDm t\u011Bl\u00EDsku k v\u00FDb\u011Bru oocyt\u016F k IVF. Diagnostika aneuploidi\u00ED pomoc\u00ED FISH/PRINS ve spermi\u00EDch ke sn\u00ED\u017Een\u00ED rizika ne\u00FAsp\u011Bchu fertilizace, potratu a v\u00FDvoje posti\u017Een\u00E9ho d\u00EDt\u011BteVy\u0161et\u0159en\u00ED mikrodele\u010Dn\u00EDch mutac\u00ED DAZ Y chromozomu, expanze CAG trinukleotid\u016F v genu androgenn\u00EDho receptoru ke zdokonalen\u00ED genetick\u00E9 prevence p\u0159enosu infertility, postnat\u00E1ln\u00EDho neurodegenerativn\u00EDho posti\u017Een\u00ED a zp\u0159esn\u011Bn\u00ED rizika v\u00FDvoje karcinomu prostaty. \u010Casn\u00E1 prenat\u00E1ln\u00ED diagnostika po IVF zdokonalen\u00FDm ultrazvukov\u00FDm a biochemick\u00FDm screeningem a vy\u0161et\u0159en\u00EDm fet\u00E1ln\u00ED DNA v krvi t\u011Bhotn\u00E9 \u017Eeny k neinvazivn\u00EDmu ur\u010Den\u00ED pohlav\u00ED, k detekci poruch placenty, rizika preeklampsie a autoimunity po porodu." . "The improvement of IVF methods by laser micromanipulation to increase biological safety and success of assisted hatching, of first polar body i biopsy, of sperm immobilization without PVP for ICSI to avoid its possible toxic impact for embryo. Molecular cytogenetic/genetic diagnosis of aneuploidies and CFTR mutations in first polar body for IVF bocyte selection. FISH/PRINS aneuploidy detection in sperms to decrease the risk of IVF failure, early abortion and development of affected child. Study of Y chromosome, DAZ mutations, of CAG trinucletiode eypansion in androgen receptor gene to improve genetic prevention of infertility transfer, postnatal neurodegenerative affection and the risk estimation of prostate cancer development. Early prenatal diagnosis after IVF by improved ultrasound, biochemical screening and by fetal DNA analysis in the pregnant women blood for non invasive sex diagnosis, for placental disorder detection, preeclampsia and autoimmunity risk after delivery."@en . "7"^^ . "Laser" . . . "http://www.isvav.cz/projectDetail.do?rowId=NE6462"^^ . "gametes" . "Vyu\u017Eit\u00ED nov\u00FDch metod laserov\u00E9 mikromanipulace, molekul\u00E1rn\u00ED cytogenetiky a genetiky ke zdokonalen\u00ED asistovan\u00E9 reprodukce a \u010Dasn\u00E9 prevence t\u011B\u017Ek\u00FDch VVV a chorob" . "The use of new methods of laser micromanipulation, of molecular cytogenetics and genetics for the improvement of assisted reproduction and of early prevention of severe congenital anomalies and disorders"@en . "Laser;gametes;CAG trinucleotides;DAZ a, b, c mutations;FISH/PRINS;QFPCR;fetal DNA;prefertilization preimplantati"@en . . "CAG trinucleotides" . "fetal DNA" . " c mutations" . "QFPCR" . . . "NE6462" . . .