. "Myocardium" . "Perinatal hypoxia is primary programming stimulus in the heart, leading to sex-dependent changes in cardiac tolerance to acute oxygen deprivation in later adult life. Tolerance\u00B4s increased in adult female rats. Effect in males was opposite."@en . "ND7607" . . . "Myocardium exposed to chronic hypoxia in the early neonatal period can show different functional and mechanical properties in adulthood compared with myocardium not affected with hypoxia, particularly in a sense of ischemic damage. Aim of project is to characterize functional resistance of myocardium of adult rats exposed neonatally to chronic hypoxia. The resistance to ischemic injury will be assessed in adult rats as an infarct size, severity of ischemic/reperfusion arrhythmias and recovery of contractile function. Achieved results can remarkably affect the therapeutic strategy in adult patient with corrected CHD."@en . . . . . . "Neonatal hypoxia;Myocardium;Resistance;Myocardial infarction;Ventricular arrhythmias;Ischemia"@en . . . . "Ventricular arrhythmias" . . . "http://www.isvav.cz/projectDetail.do?rowId=ND7607"^^ . . . "Vliv neonat\u00E1ln\u00ED hypoxie na odolnost dosp\u011Bl\u00E9ho srde\u010Dn\u00EDho svalu k nedostatku kysl\u00EDku." . . "Myocardial infarction" . "Vypracov\u00E1na metoda hodnocen\u00ED velikosti infark.lo\u017Eiska na isolov.perfundov.srdci potkana. Perinat\u00E1l.hypoxie ovliv\u0148uje odolnost dosp\u011Bl.srde\u010D.svalu k nedostatku C2O v z\u00E1vislosti na pohlav\u00ED.Srdce spont\u00E1nn\u011B hypertenz. potkan\u016F je m\u00E9n\u011B odoln\u00E9 ne\u017E normotenzn\u00EDch."@cs . "0"^^ . "2"^^ . "2"^^ . "2006-06-23+02:00"^^ . "1"^^ . "Myokard, vystaven\u00FD v neonat\u00E1ln\u00EDm obdob\u00ED chronick\u00E9 hypoxemii ( nap\u0159. u vrozen\u00FDch cyanotick\u00FDch srde\u010Dn\u00EDch vad) m\u016F\u017Ee v dosp\u011Blosti vykazovat odli\u0161nou odolnost k akutn\u00EDmu nedostatku kysl\u00EDku. C\u00EDlem projektu je proto charakterizovat funk\u010Dn\u00ED vlastnosti myokardu dosp\u011Bl\u00FDch potkan\u016F, vystaven\u00FDch v neonat\u00E1ln\u00EDm obdob\u00ED hypoxemii a zjistit odolnost jejich srdce k akutn\u00ED ischemii. Odolnost k ischemick\u00E9mu po\u0161kozen\u00ED bude hodnocena u dosp\u011Bl\u00FDch zv\u00ED\u0159at velikost\u00ED infarktu, z\u00E1va\u017Enost\u00ED ischemicko-reperfuzn\u00EDch arytmi\u00ED a reparac\u00ED kontraktiln\u00ED funkce. Dosa\u017Een\u00E9 v\u00FDsledky by mohly v\u00FDznamn\u00FDm zp\u016Fsobem ovlivnit terapeutickou strategii u dosp\u011Bl\u00FDch pacient\u016F s operovan\u00FDmi vrozen\u00FDmi cyanotick\u00FDmi vadami." . "1"^^ . . "Resistance" . "The effect of neonatal hypoxia on the resistance of the adult myocardium to oxygen deficiency."@en . "Neonatal hypoxia" . . .