"2006-06-23+02:00"^^ . . "0"^^ . . . . "Predikce l\u00E9\u010Debn\u00E9 odpov\u011Bdi nemocn\u00FDch s resekabiln\u00EDm metastatick\u00FDm posti\u017Een\u00EDm jater u kolorekt\u00E1ln\u00EDho karcinomu." . "Exprese enzym\u016F jsme stanovovali ze vzork\u016F z metast\u00E1z i ze zdrav\u00E9 jatern\u00ED tk\u00E1n\u011B. Zji\u0161t\u011Bn\u00E1 exprese byla v souladu s p\u0159edpokladem o \u00FA\u010Dinnosti adjuvantn\u00ED chemoterapie. Vzhledem k velikosti souboru nen\u00ED mo\u017En\u00E9 dosa\u017Een\u00E9 v\u00FDsledky statisticky hodnotit."@cs . . . . . . . . "V \u010Cesk\u00E9 Republice ro\u010Dn\u011B nov\u011B onemocn\u00ED kolorekt\u00E1ln\u00EDm karcinomem asi 7000 osob. Asi u poloviny z nich jsou synchronn\u00ED nebo metachronn\u00ED metast\u00E1zy v jatrech. Radik\u00E1ln\u00ED resekce jater je v sou\u010Dasn\u00E9 dob\u011B jedin\u00FD efektivn\u00ED zp\u016Fsob l\u00E9\u010Dby. Rekurenci ve zbytku jatern\u00ED tk\u00E1n\u011B vyvine v\u00EDce ne\u017E polovina nemocn\u00FDch. Je uv\u00E1d\u011Bno, \u017Ee lokoregion\u00E1ln\u00ED adjuvantn\u00ED chemoterapie sni\u017Euje riziko rekurence ve zb\u00FDvaj\u00EDc\u00ED jatern\u00ED tk\u00E1ni. Z\u00E1kladem chemoterpie kolorekt\u00E1ln\u00EDho karcinomu z\u016Fst\u00E1v\u00E1 5 fluorouracil. Z exprese enzym\u016F z\u00FA\u010Dastn\u011Bn\u00FDch v metabolismu 5 fluorouracilu (5-FU) lze definovat skupinu pacient\u016F, kte\u0159\u00ED budou z adjuvantn\u00ED chemoterapie 5-FU profitovat, tedy lze predikovat l\u00E9\u010Debnou odpov\u011B\u010F pacienta. Nebyl publikov\u00E1n vztah mezi expres\u00ED enzym\u016F metabolizuj\u00EDc\u00EDch 5-FU, stanoven\u00E9 v materi\u00E1lu z\u00EDskan\u00E9m z n\u00E1dorov\u00E9 tk\u00E1n\u011B RO resekovan\u00FDch jatern\u00EDch metast\u00E1z KR-Ca a efektem adjuvantn\u00ED HAIC do zbyl\u00E9 jatern\u00ED tk\u00E1n\u011B na rekurenci onemocn\u011Bn\u00ED." . "Expressions of enzymes were evaluated both from healthy liver tissue and from metastases. The expression responds to expected outcome of adjuvant chemotherapy. Low number of patient does not permit statistic evaluation."@en . . "colorectal cancer;liver metastasis;adjuvant chemotherapy"@en . "colorectal cancer" . . "Prediction of the therapeutic response by patients with resectable metastatic liver disease in colorectal carcinoma (CR-Ca)."@en . "liver metastasis" . . . "Each year, about 7,000 persons develop colorectal cancer in the Czech Republic. About half of them are shown to have synchronic and metachronic metastases in the liver. Radical liver resection is currently the only effective technique of treatm Recurrence in residual hepatic tissue develops in ore than a half of patients. It is reported that locoregional adjuvant chemotherapy reduces the risk of recurrence in residual hepatic tissue. The mainstay of colorectal carcinoma therapy remai Using the expression of enzymes involved in 5-fluorouracil (5-FU) metabolism, a group of patients can be defined who will benefit from adjuvant 5-FU chemotherapy; as a result, the therapeutic response by the patient can be predicted. To date, there has been no publication on the expression of 5-FU metabolizing enzymes, as determined in material obtained from malignant tissue of RO resected hepatic metastases of CR-Ca and the effect of adjuvant HAIC into residual hep ."@en . "ND7575" . "2"^^ . . "2"^^ . "1"^^ . . . "http://www.isvav.cz/projectDetail.do?rowId=ND7575"^^ . "1"^^ . .