. . . "14"^^ . "14"^^ . . . "0"^^ . "tissue perfusion" . "To investigate the hypothesis that manipulating the perfusion pressure, though in the physiologic range, may have different efect on hepato-splanchnic macro- and microcirculation, oxygen balance and energy metabolism. The effects of two different levels of mean arterial pressure (65 and 85 mmHg) achieved by titrating norepinephrine will be studied in patients with and without history of arterial hypertension."@en . . . . "1"^^ . . "1"^^ . "Manipulace s tk\u00E1\u0148ov\u00FDm perf\u00FAzn\u00EDm tlakem u septick\u00E9ho \u0161oku: vliv na hemodynamiku a energetick\u00FD metabolismus hepatosplanchnick\u00E9ho syst\u00E9mu" . . . "sepsis;splanchnic blood flow;shock;metabolism;norepinephrine;laser-Doppter;tissue perfusion;gut tonometry"@en . "metabolism" . . "Z experiment. i klin. v\u00FDsledk\u016F projektu vypl\u00FDv\u00E1, \u017Ee noradrenalinem navozen\u00E1 manipulace s perf\u00FAzn\u00EDm tlakem v septick\u00E9m \u0161oku nad \u00FArovn\u00ED autoregula\u010Dn\u00EDho pr\u00E1hu neovliv\u0148uje jak hemodynamiku tak energetick\u00FD metabolismus hepatosplanchnick\u00E9ho syst\u00E9mu."@cs . . . "splanchnic blood flow" . . . "http://www.isvav.cz/projectDetail.do?rowId=ND6989"^^ . "laser-Doppter" . "shock" . . . . "2006-06-23+02:00"^^ . "norepinephrine" . "Results of our studies show that norepinephrine-induced manipulations with perfusion pressure (above autoregulatory threshold) in septic shock exhibited neither beneficial nor deleterious effects on hepatosplanchnic hemodynamics and energetic metabolism."@en . . "sepsis" . "ND6989" . "Tissue perfusion pressure manipulation in septic shock: efeect on hepatosplanchnic hemodynamics and energy metabolism"@en . "\u0158e\u0161en\u00ED hypot\u00E9zy, \u017Ee r\u016Fzn\u00E9 \u00FArovn\u011B st\u0159edn\u00EDho arteri\u00E1ln\u00EDho tlaku mohou m\u00EDt u nemocn\u00FDch v septick\u00E9m \u0161oku odli\u0161n\u00FD dopad na makro- a mikrocirkulaci a energetick\u00FD metabolismus hepato-splanchnick\u00E9ho szst\u00E9mu. Vliv dvou odli\u0161n\u00FDch fyziologick\u00FDch hodnot st\u0159edn\u00EDho arteri\u00E1ln\u00EDho tlaku (65 a 85 mmHg) dosa\u017Een\u00FDch titrov\u00E1n\u00EDm d\u00E1vky noradrenalinu bude studov\u00E1n u nemocn\u00FDch s anamn\u00E9zou arter\u00E1ln\u00ED hypertenze a u normotonik\u016F." .