. "Interaction of nitric oxide, peroxynitrite and oxidative stress in clinically relevant model of septic shock in pig"@en . . "http://www.isvav.cz/projectDetail.do?rowId=ND6837"^^ . "nitric oxide" . . . "0"^^ . "nitric oxide;iNOS;peroxynitrite;oxidative stress;septic shock"@en . . "ND6837" . . "0"^^ . . "24"^^ . "24"^^ . . . "Z\u00E1v\u011Bry p\u0159in\u00E1\u0161\u00ED d\u016Fle\u017Eit\u00E9 patofyziologick\u00E9 z\u00E1sady pro l\u00E9\u010Den\u00ED septick\u00E9ho \u0161oku. Jde o z\u00E1va\u017Enou n\u00E1zorovou zm\u011Bnu na u\u017E\u00EDv\u00E1n\u00ED vazopresor\u016F v l\u00E9\u010Db\u011B septick\u00E9ho \u0161oku, p\u0159edev\u0161\u00EDm na perfuzy gastrointestin\u00E1ln\u00EDho traktu."@cs . "iNOS" . . "Interakce oxidu dusnat\u00E9ho, peroxynitritu a oxidativn\u00EDho stresu u klinicky relevantn\u00EDho modelu septick\u00E9ho \u0161oku" . . "\u0158e\u0161en\u00ED \u00FAlohy selektivn\u00ED inhibice iNOS v kombinaci s neutralizac\u00ED superoxidu s c\u00EDlem zabr\u00E1nit toxick\u00E9mu vlivu NO a jeho deriv\u00E1tu peroxynitritu u septick\u00E9ho \u0161oku. Charakterizovat v\u00FDznam interakce oxid dusnat\u00FD-peroxynitrit v patofyziologii seps\u00ED indukovan\u00FDch zm\u011Bn v hepato-splanchnick\u00E9 oblasti. Projekt je realizov\u00E1n na experiment\u00E1ln\u00EDm klinicky relevantn\u00EDm, endotoxinem indukovan\u00E9m, hyperdynamick\u00E9m modelu septick\u00E9ho \u0161oku prasete, kter\u00FD \u00FAzce imituje patofyziologii septick\u00E9ho \u0161oku v klinick\u00E9 situaci." . . . . "oxidative stress" . . . "peroxynitrite" . . "To investigate the role of selective iNOS inhibition together with superoxide scavenging aimed at limiting NO-mediated cell/organ injury in septic shock. To investigate the role of nitric oxide -peroxynitrite interplay in the pathophysiology of sepsis-induced derangements in the hepato-splanchnic region. The objectives of the project will be studied in a longterm, hyperdynamic and hypermetabolic porcine model of septic shock mimicking human septic pathophysiology."@en . "2004-07-12+02:00"^^ . "1"^^ .