. . "Solubiln\u00ED leptinov\u00FD receptor a stupe\u0148 dysfagie byl zji\u0161t\u011Bn jako nez\u00E1visl\u00FD faktor pro p\u0159e\u017Eit\u00ED, pokles hmotnosti nebyl statisticky v\u00FDznamn\u00FD. S\u00E9rov\u00E9 hladiny leptinu, leptinov\u00E9ho receptoru, TNF-alfa i mastn\u00FDch kyselin zasluhuj\u00ED dal\u0161\u00ED prospektivn\u00ED sledov\u00E1n\u00ED."@cs . . "prognostic factors" . "NC7530" . "esophageal cancer;chemoradiotherapy;prognostic factors;leptin;weight loss;nutritional support"@en . . "Predictive and prognostic factors in esophageal cancer patients treated with combined modality therapy protocol-preoperative chemoradiotherapy and surgical resection"@en . . "http://www.isvav.cz/projectDetail.do?rowId=NC7530"^^ . . . "chemoradiotherapy" . "P\u0159edopera\u010Dn\u00ED chemoradioterapie s n\u00E1slednou chirurgickou resekc\u00ED pacient\u016F s karcinomem j\u00EDcnu m\u016F\u017Ee prodlou\u017Eit p\u0159e\u017Eit\u00ED. Nutri\u010Dn\u00ED deficit p\u0159\u00EDtomn\u00FD u v\u00FDznamn\u00E9 \u010D\u00E1sti pacient\u016F m\u016F\u017Ee b\u00FDt p\u0159\u00ED\u010Dinou selh\u00E1n\u00ED terapie. \u00DA\u010Delem t\u00E9to studie je zhodnotit \u00FA\u010Dinnost intenzivn\u00ED nutri\u010Dn\u00ED podpory b\u011Bhem terapie a porovnat zn\u00E1m\u00E9 prognostick\u00E9 faktory s n\u011Bkter\u00FDmi nov\u011Bj\u0161\u00EDmi parametry. Budou m\u011B\u0159eny s\u00E9rov\u00E9 hladiny leptinu, leptinov\u00E9ho receptoru, TGF-alfa, IGF-1. Bude provedena korelace laboratorn\u00EDch v\u00FDsledk\u016F s nutri\u010Dn\u00EDm stavem ( body mass index, zm\u011Bny v\u00E1hy p\u0159ed terapi\u00ED a b\u011Bhem n\u00ED), s dal\u0161\u00EDmi prognostick\u00FDmi faktory (PS, stadium, l\u00E9\u010Debn\u00E1 odpov\u011B\u010F ) a sl\u00E9\u010Debn\u00FDmi v\u00FDsledky (doba progrese, p\u0159e\u017Eit\u00ED). C\u00EDlem studie je presn\u011Bj\u0161\u00ED definice prognostick\u00FDch a prediktivn\u00EDch faktor\u016F, kter\u00E1 by vedla k individualizaci terapie a k prodlou\u017Een\u00ED p\u0159e\u017Eit\u00ED nemocn\u00FDch s karcinomem j\u00EDcnu." . . "weight loss" . . . . "0"^^ . "Soluble leptin receptor and grade of dysphagia were found as independent survival prognostic factor. Body weight loss was not statistically significant. Serum levels of leptin, soluble leptin receptor, TNF-alfa and fatty acids need prospective follow-up."@en . "leptin" . . "Hodnocen\u00ED prognostick\u00FDch a prediktivn\u00EDch faktor\u016F u nemocn\u00FDch s karcinomem j\u00EDcnu l\u00E9\u010Den\u00FDch multimod\u00E1ln\u00EDm postupem - p\u0159edopera\u010Dn\u00ED chemoradioterapi\u00ED a chirurgickou resekc\u00ED." . "1"^^ . "esophageal cancer" . . "2006-06-23+02:00"^^ . "4"^^ . "0"^^ . . "4"^^ . . . . . . "Neoadjuvant chemoradiation and consecutive surgery of patients with esophageal cancor may prolong survival. Nutritional deficit present in substantial part o patients may lead to treatment failure. Purpose of this study to evaluate efficacy of intensive nutritional support and to compare know prognostica factors with some new parameters. Serum leptin, leptin receptors, TNFalta and IGF-1 will be measured."@en . . .